Membrane proteins significantly restrict exosome mobility

Biochemical and Biophysical Research Communications
Mikhail SkliarRakesh Rachamadugu

Abstract

Exosomes are membrane nanovesicles implicated in cell-to-cell signaling in which they transfer their molecular cargo from the parent to the recipient cells. This role essentially depends on the exosomes' small size, which is the prerequisite for their rapid migration through the crowded extracellular matrix and into and out of circulation. Here we report much lower exosome mobility than expected from the size of their vesicles, implicate membrane proteins in a substantially impeded rate of migration, and suggest an approach to quantifying the impact. The broadly distributed excess hydrodynamic resistance provided by surface proteins produces a highly heterogeneous and microenvironment-dependent hindrance to exosome mobility. The implications of the findings on exosome-mediated signaling are discussed.

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Citations

Sep 29, 2018·American Journal of Respiratory Cell and Molecular Biology·Shannon H LacyRichard P Phipps
May 5, 2020·Journal of Extracellular Vesicles·Alessandro GoriMarina Cretich
Oct 9, 2020·International Journal of Molecular Sciences·Dmitry KostyushevVladimir Chulanov
Jul 8, 2020·Analytical Chemistry·Andrea RidolfiFrancesco Valle
Sep 9, 2021·Biology Open·Tania Martins-Marques
Sep 15, 2021·Journal of Extracellular Vesicles·Eszter Á TóthEdit I Buzás

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