PMID: 221669Mar 1, 1979Paper

Membrane proteins specified by herpes simplex viruses. III. Role of glycoprotein VP7(B2) in virion infectivity

Journal of Virology
M SarmientoP G Spear

Abstract

Experiments done with a temperature"sensitive mutant of herpes simplex virus type 1 (HSV-1) have revealed that one of the virisn glycoproteins, designated VP7(B2), is apparently not required for the production of enveloped virus particles, whereas it does play a critical role in virion infectivity. The mutant, designated HSV-1[HFEM]tsB5, fails to accumulate VP7(B2) at nonpermissive temperature and produces virions that lack detectable quantities of this glycoprotein and that have very low specific infectivity. The poor infectivity of the virions is most readily explained by failure of penetration into the host cell rather than by failure of adsorption to cells because it was shown that the VP7(B2)-deficient virions can bind to cells and that polyethylene glycol, an agent known to promote membrane fusion, can significantly enhance infectivity of the adsorbed virions.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R ManservigiA Buchan
May 1, 1968·Journal of Virology·C MorganB Mednis
Jul 1, 1969·Journal of Virology·K HummelerB Zajac
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J M KellerB Roizman
Jan 1, 1968·Journal of Virology·B Roizman, P G Spear
Oct 1, 1970·Canadian Journal of Microbiology·S SteinJ Mahoney
Oct 1, 1972·Virology·U Olshevsky, Y Becker
Oct 1, 1972·Virology·A S RubensteinR Darlington
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S Kawai, H Hanafusa

❮ Previous
Next ❯

Citations

Jan 1, 1986·Archives of Virology·Y KinoR Mori
Jan 1, 1987·Microbiology and Immunology·A H Koyama, T Uchida
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marisa P McShane, Richard Longnecker
Jan 1, 1980·Archives of Virology·G Campadelli-FiumeA Mannini-Palenzona
Jul 18, 2002·Oral Microbiology and Immunology·S-L HungY-T Chen
Sep 18, 2008·The Journal of General Virology·Marein A W P de JongTeunis B H Geijtenbeek
Feb 13, 2015·Journal of Clinical Microbiology·Ashley V KondasInger K Damon
Nov 28, 2014·Journal of Virology·Jun AriiYasushi Kawaguchi
Jan 1, 1988·Critical Reviews in Microbiology·M A Devaney
Apr 12, 2001·The Journal of General Virology·B F KinghamC J Schmidt
Feb 9, 2010·Natural Product Research·Thaveechai VachirayonstienPathom Sawanpanyalert
May 1, 1989·Clinical and Experimental Dermatology·M C HengJ Fazier
Jan 1, 1990·Archives of Virology·D SawitzkyK O Habermehl
May 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L Haarr, S Skulstad
Feb 8, 2003·DNA and Cell Biology·Edward A BurtonJoseph C Glorioso
Jan 1, 1979·Immunological Reviews·T J McKearnF P Stuart
Aug 8, 1998·Journal of Virology·A KargerT C Mettenleiter
Jan 28, 1998·Journal of Virology·R J Roller, D Rauch
Dec 4, 2001·Advanced Drug Delivery Reviews·E A BurtonJ C Glorioso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.