PMID: 6169565Jan 1, 1981Paper

Membrane surface properties of normal and malignant cells: partition in aqueous two-polymer phase systems

Experimental Cell Biology
G V Sherbet, M S Lakshmi

Abstract

The partition of normal and malignantly transformed fibroblast lines and cell lines initiated from malignant human astrocytomas and a benign ganglioneuroma has been examined in aqueous dextran-polyethylene glycol phase system containing phosphate buffer with a low phosphate/sodium chloride ratio. The malignant astrocytomas showed a significantly lower partition coefficient as compared with the benign ganglioneuroma. Treatment of astrocytoma cells with dexamethasone caused an increase in the partitioning of the cell population. No differences were found in the partition behaviour of normal BHK-21 cells and their malignant transformants, the TRES fibrosarcoma cells. Polyoma and simian virus-transformed 3T3 fibroblasts showed partition ratios similar to the untransformed cells. Dexamethasone pre-treatment had no effect on the partition behaviour of these cells. The significance of these observations has been discussed in relation to the surface hydrophobicity and the neoplastic state.

Citations

Jun 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·F D RaymondD W Moss
Jun 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·F D RaymondD Fisher
Mar 16, 1988·Journal of Immunological Methods·B W Hazen, K C Hazen
Feb 18, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·David Pfister, Massimo Morbidelli

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