Membrane-targeting antibiotics: recent developments outside the peptide space

Future Medicinal Chemistry
Catarina Dias, Amélia P Rauter

Abstract

The rise of antibiotic resistant bacteria requires unconventional strategies toward efficient chemotherapeutic agents, preferably with alternative mechanisms of action. The bacterial cell membrane has become an appealing target since its essential and highly conservative structure are key challenges to resistance mechanisms. Inspired by natural antimicrobial peptides, research on membrane-targeting antimicrobials has been growing out of the peptide space. The pursuit of more druggable molecules led to the discovery that the pharmacophore of antimicrobial peptides is smaller than anticipated. Several promising classes of membrane-targeting antimicrobials have been discovered, such as ceragenins, reutericyclines, carbohydrate amphiphiles - among others. This review will discuss the most recent findings on membrane-targeting antibiotics, focusing on small molecules outside the antimicrobial peptide molecular space.

References

Jul 24, 1998·Trends in Biotechnology·D D Lasic
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·M P Mingeot-LeclercqP M Tulkens
Feb 7, 2003·Current Medicinal Chemistry·Sergey B Zotchev
Apr 18, 2003·Journal of Medicinal Chemistry·Morten B StrømJohn S Svendsen
Jan 22, 2004·Applied Microbiology and Biotechnology·M G Gänzle
Jun 19, 2007·Biochimica Et Biophysica Acta·Devaki A Kelkar, Amitabha Chattopadhyay
Jun 30, 2007·Biochimica Et Biophysica Acta·Raquel F EpandRichard M Epand
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Mar 25, 2008·Biochimica Et Biophysica Acta·Rohit Sood, Paavo K J Kinnunen
Jun 24, 2008·Journal of Medicinal Chemistry·Bengt Erik HaugJohn S Svendsen
Jul 2, 2008·Infection and Immunity·Joerg OverhageRobert E W Hancock
Nov 18, 2008·The Journal of Antimicrobial Chemotherapy·Kristina FlemmingTrond Flaegstad
Jul 2, 2009·Journal of Chemical Biology·Erick J Dufourc
Jul 8, 2009·Antimicrobial Agents and Chemotherapy·Julian G HurdleRichard E Lee
Aug 14, 2009·Bioorganic & Medicinal Chemistry·Matthijs van der KnaapMark Overhand
Aug 20, 2009·The Journal of Antimicrobial Chemotherapy·Nicola OoiIan Chopra
Mar 25, 2010·The Journal of Antimicrobial Chemotherapy·Smritilekha BeraFrank Schweizer
Jun 30, 2010·Antimicrobial Agents and Chemotherapy·Raquel F EpandRichard M Epand
Dec 18, 2010·Nature Reviews. Microbiology·Julian G HurdleRichard E Lee
Apr 12, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Richard M Epand, Raquel F Epand
Jul 28, 2011·Organic & Biomolecular Chemistry·Sunil K VooturiSteven M Firestine
Dec 17, 2011·Nature Reviews. Drug Discovery·Christopher D FjellGisbert Schneider
Apr 23, 2013·Bioorganic & Medicinal Chemistry·Yifat Berkov-ZrihenMicha Fridman
Oct 3, 2013·Journal of Medicinal Chemistry·Louis ZimmermannJean-Luc Décout
Nov 30, 2013·Pharmaceuticals·Ali Adem Bahar, Dacheng Ren
Jun 8, 2014·European Biophysics Journal : EBJ·Marc-Antoine SaniFrances Separovic
Jun 14, 2014·Molecular Biology of the Cell·Eleonora MuroUlrike S Eggert
May 2, 2015·Journal of Nanobiotechnology·Katarzyna NiemirowiczRobert Bucki
Aug 8, 2015·Antimicrobial Agents and Chemotherapy·Robert BuckiPaul B Savage
Oct 23, 2015·European Journal of Medicinal Chemistry·Qiu Ying LauCheng San Brian Chia
Oct 31, 2015·Biochimica Et Biophysica Acta·Natalie J MitchellAntje Pokorny
Feb 3, 2016·Infectious Diseases and Therapy·Karrine D BradeMichael J Rybak
Sep 24, 2016·Pharmaceuticals·Nermina Malanovic, Karl Lohner

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Citations

Feb 20, 2020·Antibiotics·Marie-Joelle Virolle
Dec 22, 2020·Journal of Biochemical and Molecular Toxicology·Aparna BahugunaDiwan S Rawat
Jan 28, 2021·International Journal of Molecular Sciences·Aleksandra Tymoszewska, Tamara Aleksandrzak-Piekarczyk
Mar 10, 2021·Journal of the American Chemical Society·Rafael Santana NunesPaulo J Costa
Mar 16, 2021·ACS Omega·Alejandra Matamoros-RecioSonsoles Martín-Santamaría
Apr 16, 2021·The Journal of Antimicrobial Chemotherapy·Chieh-Hsien LuHao-Chieh Chiu
Apr 15, 2021·Annual Review of Biomedical Engineering·Ming LeiKyongbum Lee

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