Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications.

FEMS Microbiology Letters
I Soares-SilvaM Casal

Abstract

Organic acids such as monocarboxylic acids, dicarboxylic acids or even more complex molecules such as sugar acids, have displayed great applicability in the industry as these compounds are used as platform chemicals for polymer, food, agricultural and pharmaceutical sectors. Chemical synthesis of these compounds from petroleum derivatives is currently their major source of production. However, increasing environmental concerns have prompted the production of organic acids by microorganisms. The current trend is the exploitation of industrial biowastes to sustain microbial cell growth and valorize biomass conversion into organic acids. One of the major bottlenecks for the efficient and cost-effective bioproduction is the export of organic acids through the microbial plasma membrane. Membrane transporter proteins are crucial elements for the optimization of substrate import and final product export. Several transporters have been expressed in organic acid-producing species, resulting in increased final product titers in the extracellular medium and higher productivity levels. In this review, the state of the art of plasma membrane transport of organic acids is presented, along with the implications for industrial biotechnology.

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Citations

Jan 28, 2021·FEMS Microbiology Letters·Gennaro Agrimi, Matthias G Steiger
Jan 14, 2021·Journal of Fungi·Maria Sousa-SilvaIsabel Soares-Silva
Jun 1, 2021·FEMS Microbiology Letters·Rainer BreitlingEriko Takano
Sep 3, 2021·Computational and Structural Biotechnology Journal·Toni RendulićMargarida Casal

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Methods Mentioned

BETA
genetic modifications
PCR

Software Mentioned

TMHMM
DASS

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