Jan 1, 1977

Membrane water channels and SH-groups

Advances in Experimental Medicine and Biology
R I Sha'afi, M B Feinstein

Abstract

The transport of water across human red cell membranes is conmonly interpreted in terms of small aqueous channels. This interpretation is based largely on indirect evidence. In this report, two sets of experiments providing more direct evidence for this idea is presented. (1) The effect of various SH-reactive reagents on the movement of water was studied. Using these compounds we attempted to localize and characterize those membrane SH-groups which are important for water transport. (2) Experimental evidence which suggests that these channels are assembled from aggregates of specific membrane protein(s) is presented.

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Mentioned in this Paper

Serum Proteins
Sulfhydryl Compounds
Water channel
Sulfhydryl Reagents
Water Transport
Niosomes
Membrane Proteins
Red Cell Ghost
Cell Surface Proteins
Erythrocytes

About this Paper

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