Membranoproliferative glomerulonephritis type III: association of glomerular deposits with circulating nephritic factor-stabilized convertase

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
C D West, A J McAdams

Abstract

Deposits in the glomerular ultrastructure of 44 renal biopsy specimens from 21 patients with membranoproliferative glomerulonephritis (MPGN) type III have been compared with those in the ultrastructure of 34 biopsy specimens from 19 patients with MPGN type I. Previous studies have concluded that subepithelial deposits on the paramesangial portion of the glomerular basement membrane in MPGN types II and III are closely associated with circulating nephritic factor-stabilized convertase. In the present study, subendothelial deposits in MPGN type III were also found to be closely associated with nephritic factor; they were present in 14 of 26 (54%) biopsy specimens obtained during hypocomplementemia but in none of the 18 biopsy specimens obtained during normocomplementemia (P < 0.001). Subepithelial loop deposits in type III were also more frequent in biopsy specimens obtained during hypocomplementemia and are probably in some way also associated with circulating stabilized convertase. Taken together, the results of this and previous studies are compatible with the hypothesis that an excess of the C3b-dependent convertase in the circulation is basic to the pathogenesis of MPGN types II and III as well as of several other nephritide...Continue Reading

Citations

Nov 13, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bassam Alchi, David Jayne
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Mar 16, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jennifer A McCaughanAisling E Courtney
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·John NearyPeter Conlon
Jun 25, 2013·Molecular Immunology·Marie-Agnès Dragon-DureyLeendert A Trouw
Jul 28, 2016·World Journal of Nephrology·Maurizio Salvadori, Giuseppina Rosso
Feb 6, 2007·Annals of Saudi Medicine·T T AntonovychB B Broumand
Jul 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ralph KettritzFriedrich Luft
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaobo WuJohn P Atkinson
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·John J NearyMichelle P Winn
Apr 9, 2001·Journal of Immunological Methods·E JelezarovaH U Lutz

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