Membranous nephropathy associated with multicentric Castleman's disease that was successfully treated with tocilizumab: a case report and review of the literature.

BMC Nephrology
Ryosuke SaikiKaoru Dohi

Abstract

Multicentric Castleman's disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications of Castleman's disease include AA amyloidosis, thrombotic microangiopathy, and membranoproliferative glomerulonephritis, membranous nephropathy is relatively rare. We experienced a case of secondary membranous nephropathy associated with Castleman's disease. The patient was a 43-year-old Japanese man who had shown a high zinc sulfate value in turbidity test, polyclonal hypergammaglobulinemia, anemia, and proteinuria. A physical examination revealed diffuse lymphadenopathy, an enlarged spleen and papulae of the body trunk. A skin biopsy of a papule on the patient's back showed plasma cells in the perivascular area and he was diagnosed with multicentric Castleman's disease, plasma cell variant. Kidney biopsy showed the appearance of bubbling in the glomerular basement membranes in Periodic acid methenamine silver stain and electron microscopy revealed electron dense deposits within and outside the glomerular basement membranes. Since immunofluorescence study showed predominant granular deposition of IgG1 and IgG2, he was di...Continue Reading

References

Jul 1, 1956·Cancer·B CASTLEMANV P MENENDEZ
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Jul 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Khalil El KarouiEric Daugas
May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Damin XuHong Zhang
Aug 9, 2011·Clinical and Experimental Nephrology·Xiang-Gui YuanXiao-Ying Zhao
Mar 1, 2012·Annals of Surgery·Nadia TalatKlaus-Martin Schulte
Apr 12, 2016·The Lancet. Haematology·Amy Y LiuDavid C Fajgenbaum
Feb 12, 2017·BMC Nephrology·Anubha MutnejaYing Maggie Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Annals of the Rheumatic Diseases
A RiccioA Puzziello
American Journal of Hematology
Alexander SlotwinerStephan Moll
Atencion primaria
M AlonsoP Luna
Journal of Insurance Medicine
David S Williams
Plućne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology
J OrelB Hrabar
© 2021 Meta ULC. All rights reserved