Abstract
Multicentric Castleman's disease is a life-threatening disorder involving a systemic inflammatory response and multiple organ failure caused by the overproduction of interleukin-6. Although renal complications of Castleman's disease include AA amyloidosis, thrombotic microangiopathy, and membranoproliferative glomerulonephritis, membranous nephropathy is relatively rare. We experienced a case of secondary membranous nephropathy associated with Castleman's disease. The patient was a 43-year-old Japanese man who had shown a high zinc sulfate value in turbidity test, polyclonal hypergammaglobulinemia, anemia, and proteinuria. A physical examination revealed diffuse lymphadenopathy, an enlarged spleen and papulae of the body trunk. A skin biopsy of a papule on the patient's back showed plasma cells in the perivascular area and he was diagnosed with multicentric Castleman's disease, plasma cell variant. Kidney biopsy showed the appearance of bubbling in the glomerular basement membranes in Periodic acid methenamine silver stain and electron microscopy revealed electron dense deposits within and outside the glomerular basement membranes. Since immunofluorescence study showed predominant granular deposition of IgG1 and IgG2, he was di...Continue Reading
References
Jan 1, 1990·American Journal of Nephrology·G RuggieriV Marinozzi
Jul 1, 1956·Cancer·B CASTLEMANV P MENENDEZ
Jan 22, 2004·Biochemical and Biophysical Research Communications·Keisuke HagiharaKazuyuki Yoshizaki
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Jul 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Khalil El KarouiEric Daugas
May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Damin XuHong Zhang
Aug 9, 2011·Clinical and Experimental Nephrology·Xiang-Gui YuanXiao-Ying Zhao
Mar 1, 2012·Annals of Surgery·Nadia TalatKlaus-Martin Schulte
Dec 17, 2015·Internal Medicine·Takashi IijimaYoshifumi Ubara
Apr 12, 2016·The Lancet. Haematology·Amy Y LiuDavid C Fajgenbaum
Jan 15, 2017·Blood·David C FajgenbaumMegan S Lim
Feb 12, 2017·BMC Nephrology·Anubha MutnejaYing Maggie Chen
Jul 3, 2019·Nephrology·Ping-Ping SunLi Yang
Jul 19, 2019·Frontiers in Immunology·Amélie LeursLouis Terriou
Jul 28, 2020·CEN Case Reports·Norihiro FuruteraHirotaka Shibata