Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR).

Clinical and Experimental Nephrology
Hitoshi YokoyamaCommittee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry in the Japanese

Abstract

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults. The J-RBR/J-KDR registry developed by the Japanese Society of Nephrology provides nationwide cohort data for epidemiological studies of MN. MN was present in 36.8% of 1,203 primary nephrotic syndrome patients in Japan. In addition, 633 (77.9%) out of 813 MN patients were referred to as "idiopathic," whereas 22.1% were classified as "secondary" and involved conditions such as systemic lupus erythematosus, drug exposure, infections, cancer, and various collagen diseases. The mean age of the MN patients was 62.2 (2-88) years old, their mean eGFR was 76.7 (7.6-154.6) ml/min/1.73 m(2), and 63.3% had hypertension at the time of renal biopsy. On the basis of these findings, half of Japanese idiopathic MN patients have risk factors (age >60, male, or lower eGFR) for end-stage renal failure, and 10% belong to the high-risk group (daily proteinuria of over 8.0 g). Further studies with high-grade evidence should resolve the natural history and therapeutic problems of idiopathic MN in elderly Japanese.

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Citations

Feb 7, 2013·Clinical and Experimental Nephrology·Hitoshi SugiyamaUNKNOWN Japanese Society of Nephrology
Nov 23, 2015·Clinical and Experimental Nephrology·Hitoshi YokoyamaSeiichi Matsuo
Oct 23, 2018·Internal Medicine Journal·Mohammed AlawamiBasil Alnasrallah
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Jul 16, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hitoshi Yokoyama
Aug 8, 2020·Clinical and Experimental Nephrology·Takaya OzekiUNKNOWN Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology
Jul 16, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Shinichi Nishi
Sep 10, 2014·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Hitoshi Yokoyama
May 8, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomomi AizawaHiroshi Tanaka
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Oct 15, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yosuke InagumaRyojiro Tanaka

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