PMID: 8611361Feb 1, 1996Paper

Membranous nephropathy, interstitial nephritis, and Fanconi syndrome-- glomerular antigen

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
S P MakkerJ Huang

Abstract

We characterized the glomerular antigen of membranous nephropathy (MN) in a child with the triad of MN, proximal renal tubular basement membrane autoantibody (TBMAb)-associated interstitial nephritis (ITN), and Fanconi syndrome. Granular staining was demonstrated for human gp600 in the vicinity of immune deposits of MN along glomerular capillary loops, using a monospecific polyclonal antibody to human gp600 by indirect immunofluorescence. However, no staining was observed in the MN deposits for receptor-associated protein. Membranous nephropathy preceded the development of TBMAbs, ITN, and Fanconi syndrome by 1 year, showing that the MN lesion does not result from the initial immunological injury to the tubulointerstitium, as postulated earlier. We confirmed the reactivity of TBMAbs with the recently described rabbit 58-kilodalton (kDa) tubular basement membrane antigen (TBMAg). However, this is the first report to show reactivity of these antibodies with the human 58-kDa protein. Also, we found that TBMAg is comprised of a single protein band of 58 kDa, unlike the previously described combination of two protein band (58 kDa and 175 kDa). In this patient, following prednisone treatment, the TBMAbs became undetectable, and the n...Continue Reading

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Citations

Sep 1, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mehul P DixitRaymond Nagle
Dec 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohan ShenoyNadeem Moghal
Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Severin Kengne-WafoFrancesco Emma
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samih H NasrVivette D D'Agati
Dec 3, 2014·Néphrologie & thérapeutique·Morgane WetzsteinGabriel Choukroun
Aug 16, 2011·Seminars in Nephrology·Sudesh P Makker, Alfonso Tramontano
Feb 4, 2014·The Journal of Rheumatology·Gustavo Martelli PalominoEduardo A Donadi
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G S MarkowitzV D D'Agati

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