Membranous Nephropathy with Crescent after Hematopoietic Cell Transplantation

Internal Medicine
Mineaki KitamuraTomoya Nishino

Abstract

A 44-year-old man who received allogenic hematopoietic stem cell transplantation after being diagnosed with acute myeloid leukemia developed nephrosis when the dose of tacrolimus was tapered. A renal biopsy showed the granular deposition of immunoglobulin G in the glomerular basement membrane and subepithelial electron-dense deposits, crescent formation, C4d-positive staining of the peritubular capillary, and subendothelial swelling, suggesting that the main pathological diagnosis was membranous nephropathy and that chronic graft-versus-host disease played a role in the etiology of nephrosis. We herein report a case of membranous nephropathy with various pathological findings. C4d deposition suggests complement activation and the involvement of humoral factors.

References

Mar 13, 2003·Kidney International·J Charles Jennette
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Kirsten BrukampBorut Cizman
Dec 17, 2009·American Journal of Physiology. Renal Physiology·Takamoto OhseStuart J Shankland
Nov 3, 2010·Haematologica·Caron A Jacobson, Jerome Ritz
Dec 1, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenPatrick D Walker
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasUNKNOWN Banff meeting report writing committee
Apr 9, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Erika F RodriguezLynn D Cornell
Oct 12, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cathryn J Byrne-DuganIbrahim Batal
Apr 19, 2015·Current Opinion in Nephrology and Hypertension·Henrik DimkeSusan E Quaggin
Jun 9, 2016·The New England Journal of Medicine·Sangeeta Hingorani

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