PMID: 11624349Oct 20, 2001Paper

Memoirs on Chlorodyne and Shinyaku

Yakushigaku zasshi. The Journal of Japanese history of pharmacy
K Ohashi

Abstract

Dr. J. Collins Browne, a British army surgeon in India, invented a secret remedy for cholera-infected patients in the fifth decade of the 19th century. After his resignation from the army, the formula was given to a pharmacist in London for the purpose of manufacture and marketing as a patented medicine named Chlorodyne. Chlorodyne was well-accepted as paregoric for several decades. The formula of Chlorodyne was adopted in the 3rd Revision of the British Pharmacopoeia (1885) as "Compound Tincture of Chloroform and Morphine." In 1906, the 3rd Revision of Japanese Pharmacopoeia listed "Compound Tincture and Morphine" according to the formula of the 4th Revision of British Pharmacopoeia (1898). References written in 1870 and 1873 recorded the importation of Chlorodyne to Japan. In 1871, Dr. Jyun Matsumoto, Chief Military Surgeon Major General advised the manufacturers of traditional medicines to produce patented medicines to spread in western countries. Preparations of formula seeming to resemble Chlorodyne was named "Shinyaku" and were marketed from 1872. The name Shinyaku represented a medicine of marvellous efficacy, because the word split, Shin and Yaku, means "divine or almighty" and "medicine," respectively. Although the org...Continue Reading

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