Memory and exploratory behavior impairment in ovariectomized Wistar rats

Behavioral and Brain Functions : BBF
Sefirin DjiogueDieudonne Njamen

Abstract

Estrogen deficiency is linked to changes in several physiological processes, but the extent to which it associates with cognitive changes in menopause context is controversial. We evaluated the impact of ovariectomy on memory processes and normal exploratory behavior in Wistar rats. Young adult rats (4-6 months) were either ovariectomized (OVX group) (N = 10), sham operated (N = 10), or untouched (naïve controls) (N = 8). Afterwards, they were monitored for 12 weeks during which their cognitive functions were evaluated at first week (S1), second (S2), every 3 weeks (S5, S8) and then at week 12 (S12) using: (i) object recognition test to evaluate the short-term and long-term non-spatial memory; (ii) the object placement test to assess the spatial memory; and (iii) normal exploratory behavior components like locomotor and vertical activities in an open field arena. Marked changes in ovariectomized rats were observed in long-term non-spatial memory (~ 40% change vs. naïve and sham, P < 0.001) and spatial memory (~ 30% change, P < 0.05) from S2. Instead, from S5 the exploratory behavior was affected, with decreases in line crossing and rearing episode numbers (~ 40% change, P < 0.01), and in the time spent in the center of open fie...Continue Reading

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Citations

Aug 14, 2020·Nutritional Neuroscience·Gerardo Lorenzana-MartínezJacinto Bañuelos-Pineda
Nov 30, 2019·Frontiers in Behavioral Neuroscience·Anousheh Bakhti-SurooshWendy J Lynch
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lina LiuFei Qiao
Jul 30, 2019·Clinical and Experimental Pharmacology & Physiology·Maryam ZakeriMohammad Allahtavakoli
Oct 30, 2020·Frontiers in Endocrinology·Emese RenczésPeter Celec

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