Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children.

Proceedings of the National Academy of Sciences of the United States of America
Francis Maina NdunguKevin Marsh

Abstract

Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC responses in two populations of children: (i) previously exposed children who had documented Pf infections several years ago, but minimal exposure since then; and (ii) persistently exposed children living in a separate but nearby endemic area. We found that although Pf-specific plasma Abs were lower in previously exposed children compared with persistently exposed children, their cognate MBCs were maintained at similar frequencies. We conclude that serological analysis by itself would greatly underestimate the true memory of Pf-specific Ab responses in previously exposed children living in areas where Pf transmission has been reduced or eliminated.

References

Jan 1, 1992·Parasitology·K Marsh
Sep 1, 1991·The American Journal of Tropical Medicine and Hygiene·A SabchareonP Druilhe
Jan 20, 1990·Lancet·P Stewart, M Cohn
Aug 1, 1984·Infection and Immunity·J A Vande WaaR Bayoumi
Mar 1, 1997·The Journal of Infectious Diseases·R B WainwrightB J McMahon
Dec 5, 1998·International Journal of Epidemiology·M BöttigerA Svensson
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M TannerT Smith
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithH P Beck
Dec 14, 2002·Science·Nadia L BernasconiAntonio Lanzavecchia
Feb 25, 2003·The Journal of Infectious Diseases·Samson M KinyanjuiKevin Marsh
Nov 25, 1961·Nature·S COHENS CARRINGTON
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shane CrottyRafi Ahmed
May 8, 2004·Seminars in Immunology·Shane Crotty, Rafi Ahmed
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley
Apr 20, 2005·The Journal of Infectious Diseases·Chris J DrakeleyEleanor M Riley
May 5, 2005·The Journal of Infectious Diseases·Tabitha W MwangiKevin Marsh
Jun 9, 2005·Tropical Medicine & International Health : TM & IH·Tabitha W MwangiKevin Marsh
Jan 28, 2006·Parasite Immunology·K Marsh, S Kinyanjui
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip BejonAdrian V S Hill
Nov 17, 2007·Malaria Journal·Emelda A OkiroRobert W Snow
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Jan 6, 2009·Tropical Medicine & International Health : TM & IH·W P O'MearaK Marsh
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter D CromptonSusan K Pierce
Apr 22, 2009·Cell Host & Microbe·Audrey CombeRobert Ménard
Jun 6, 2009·Tropical Medicine & International Health : TM & IH·Kamini MendisWalther H Wernsdorfer
Sep 2, 2010·PloS One·Serign J CeesayDavid J Conway

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Citations

Apr 9, 2013·Trends in Parasitology·Anja Scholzen, Robert W Sauerwein
Nov 2, 2013·Trends in Parasitology·Danielle I StanisicMichael F Good
Jan 16, 2013·The Journal of Experimental Medicine·Matthias F MuellenbeckHedda Wardemann
Apr 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paulina AmpomahLars Hviid
Mar 25, 2014·Annual Review of Immunology·Peter D CromptonSusan K Pierce
Apr 11, 2014·The Journal of Infectious Diseases·Michael T WhiteAzra C Ghani
Jun 28, 2014·The Journal of Infectious Diseases·Wiebke NahrendorfRobert W Sauerwein
Jan 8, 2016·Parasitology·Freya J I FowkesJames G Beeson
Jan 9, 2016·Parasitology·Victoria Ryg-CornejoDiana S Hansen
Dec 29, 2015·Trends in Parasitology·Beatriz GalatasAlfredo Mayor
Dec 21, 2012·European Journal of Immunology·Modesta N Njau, Joshy Jacob
Jul 25, 2013·European Journal of Immunology·Francis M NdunguAnna Färnert
Jan 19, 2015·Trends in Parasitology·Lars HviidFreya J I Fowkes
Oct 30, 2016·Frontiers in Microbiology·Susanne H HodgsonSimon J Draper
Oct 22, 2016·Cell·Alan F CowmanKevin Marsh
Aug 12, 2015·The American Journal of Tropical Medicine and Hygiene·Christopher L KingBryan Greenhouse
May 7, 2016·Circulation Research·Anthony O EtyangJ Anthony G Scott
Nov 6, 2018·ELife·Damián Pérez-MazliahJean Langhorne
May 31, 2019·Journal of Hypertension·Massimo Volpe, Allegra Battistoni
Mar 31, 2020·European Journal of Immunology·Racheal AyeFrancis M Ndungu
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia PortugalPeter D Crompton
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evelyn N GitauBritta C Urban
Jan 4, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Severin ZinöckerSusan K Pierce
Aug 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pilar RequenaCarlota Dobaño
Apr 20, 2019·Frontiers in Immunology·Ann Ly, Diana S Hansen
Nov 17, 2019·Immunological Reviews·Damián Pérez-MazliahJean Langhorne
Jun 28, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel M MuemaBritta C Urban
Jan 11, 2019·Science Translational Medicine·James G BeesonMichelle J Boyle
Dec 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph IllingworthFrancis M Ndungu

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