PMID: 6966317May 1, 1980Paper

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors

The Journal of Experimental Medicine
L A HerzenbergL A Herzenberg

Abstract

The following evidence, mainly presented here, suggests that IgD receptors play a crucial role in determining the potential for affinity maturation in memory B cell populations. IgD receptors are present on the first memory B cells to appear after priming. These memory cells give rise to more-mature memory cells that have lost their IgD receptors. The proportions of early (IgD(+)) and mature (IgD(-)) memory cells found in individual donors vary with time, priming conditions, and the availability of T cell help, and both populations frequently coexist for long periods of time. IgD(+) and IgD(-) memory cells carry IgG receptors and give rise to IgG responses with identical isotype representation in adoptive recipients. IgD(+) memory cells, however, always give rise to predominantly low-affinity antibody responses, whereas IgD(-) memory cells consistently generate responses of substantially higher average affinity. This affinity differential is maintained between early and mature memory populations in the same donor and does not appear to be a result of selective differentiation of higher-affinity IgD(+) memory cells into the IgD(-) memory pool. Thus, the selective forces responsible for affinity maturation appear to operate mainl...Continue Reading

References

Apr 1, 1978·The Journal of Experimental Medicine·S J BlackL A Herzenberg
Jul 1, 1979·The Journal of Experimental Medicine·S J Black, L A Herzenberg
Aug 1, 1976·The Journal of Experimental Medicine·K OkumuraL A Herzenberg
Jan 1, 1975·Transplantation Reviews·L A HerzenbergC M Metzler
Jan 15, 1974·Biochemistry·M F JohnstonJ M Sturtevant

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Citations

Sep 30, 1982·Journal of Immunological Methods·T Francus, G W Siskind
Dec 17, 1985·Journal of Immunological Methods·H NygrenM Stenberg
Jan 24, 1990·Journal of Immunological Methods·E GherardiC Milstein
Jun 28, 1995·Journal of Immunological Methods·J RoesK Rajewsky
May 10, 2003·Journal of Immunological Methods·Takeyuki ShimizuTakachika Azuma
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N HirayamaZ Ovary
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaR R Hardy
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R R PollockM D Scharff
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L NitschkeM C Lamers
May 1, 1980·The Journal of Experimental Medicine·V T OiL A Herzenberg
Sep 1, 1981·The Journal of Experimental Medicine·T TokuhisaL A Herzenberg
Feb 1, 1982·The Journal of Experimental Medicine·N A Speck, S K Pierce
Jun 1, 1982·The Journal of Experimental Medicine·L A Herzenberg, T Tokuhisa
Sep 1, 1982·The Journal of Experimental Medicine·T TokuhisaM Taniguchi
Apr 5, 2000·The Journal of Experimental Medicine·L J McHeyzer-WilliamsM G McHeyzer-Williams
Nov 6, 2002·The Journal of Experimental Medicine·Robert A BarringtonMichael C Carroll
Nov 3, 2004·The Journal of Experimental Medicine·Yuchun NieYong-Rui Zou
Jun 23, 2010·The Journal of Experimental Medicine·Cristina L SwansonRaul M Torres
Jan 18, 2012·The Journal of Experimental Medicine·Huizhong XiongJuan J Lafaille
Sep 11, 2013·The Journal of Experimental Medicine·Jay W ChaplinEdward A Clark
Mar 18, 2005·Annual Review of Immunology·Louise J McHeyzer-Williams, Michael G McHeyzer-Williams
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·M R EhrensteinM S Neuberger
Feb 3, 1997·The Journal of Experimental Medicine·S LebecqueY J Liu
May 10, 2015·International Immunology·Benjamin G Chousterman, Filip K Swirski
Jan 1, 1982·Annals of the New York Academy of Sciences·D LafrenzS Strober
Jan 1, 1982·Immunological Reviews·L A HerzenbergL A Herzenberg
Jan 1, 1982·Annals of the New York Academy of Sciences·E S Vitetta
Jan 1, 1982·Annals of the New York Academy of Sciences·E S MetcalfF D Finkelman
Jan 1, 1982·Annals of the New York Academy of Sciences·L A Herzenberg

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