Memory-based comparison process not attenuated by haloperidol: a combined MEG and EEG study

Neuroreport
Eero PekkoneIiro P Jääskeläinen

Abstract

Auditory P50 and N100 responses reflect preattentive processing, whereas subsequent mismatch negativity (MMN) response indexes memory-based comparison process. Divergent ERP responses have been found in schizophrenia and in Parkinson's disease (PD), which have abnormalities in cerebral dopamine activity. We used simultaneously magnetoencephalography and electroencephalography to investigate, whether a single dose of haloperidol, a dopamine D2-receptor antagonist, modulates preattentive auditory processing using a randomized, double-blind, placebo-controlled crossover design. Our results showed that haloperidol did not alter MMN to frequency and duration changes, whereas the magnetic MMN to frequency change was significantly accelerated. The amplitude and latency changes of the electric and magnetic P50 and N100 were insignificant. Our results indicate that memory-based sound comparison and preceding cortical processing underlying stimulus detection are not attenuated by haloperidol, whereas haloperidol appears to accelerate preattentive sound comparison.

References

May 1, 1992·Neurology·J B GreenJ D Schwankhaus
Aug 1, 1994·Biological Psychiatry·J M FordA Pfefferbaum
Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·G Adler, W F Gattaz
Sep 1, 1996·Neuroscience·S K Goldsmith, J N Joyce
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·D C JavittJ C Arezzo
Nov 3, 1998·Biological Psychiatry·D UmbrichtJ Kane
Sep 9, 1999·Schizophrenia Bulletin·E PekkonenJ Tiihonen
Jun 22, 2000·Audiology & Neuro-otology·E Pekkonen
Aug 8, 2001·Brain Research. Cognitive Brain Research·I Kreitschmann-AndermahrH Sauer
Sep 15, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S KähkönenE Pekkonen

❮ Previous
Next ❯

Citations

Oct 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J Leon Kenemans, Seppo Kähkönen
Jan 4, 2008·ILAR Journal·Michael A Nader, Paul W Czoty
May 14, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Laura F MartinMichael A Kisley
Apr 4, 2012·Journal of Psychiatry & Neuroscience : JPN·Manreena KaurDaniel F Hermens
Jan 7, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Risto NäätänenHirooki Yabe
Dec 16, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R NäätänenC Ponton
May 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·J SalazarV Belloch
Oct 18, 2008·Psychiatry Research·Timm RosburgJudith M Ford
Feb 12, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Derek J FisherVerner J Knott
Dec 15, 2007·Epilepsy & Behavior : E&B·Carrie R McDonald
Feb 15, 2005·Psychiatry Research·Seppo KähkönenJyrki Ahveninen
Mar 7, 2015·Brain : a Journal of Neurology·Arnim Johannes GaeblerMikhail Zvyagintsev
Feb 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marta I GarridoKarl J Friston
Jul 16, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Manreena KaurDaniel F Hermens
Jun 13, 2014·Journal of Psychopharmacology·Suresh D Muthukumaraswamy
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Timm RosburgHeinrich Sauer
Jan 30, 2020·Psychiatry and Clinical Neurosciences·Tetsuya ShigaHirooki Yabe
May 28, 2019·Frontiers in Pharmacology·Aleksander A AleksandrovRaul R Gainetdinov
Mar 11, 2020·Brain Research Bulletin·Aleksander A AleksandrovNadezhda V Polyakova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The International Journal of Neuropsychopharmacology
Daniel UmbrichtJ Kane
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Seppo KähkönenE Pekkonen
Psychiatry Research
Seppo KähkönenJyrki Ahveninen
Brain Research. Cognitive Brain Research
I Kreitschmann-AndermahrH Sauer
© 2022 Meta ULC. All rights reserved