Memory Deficit in an Object Location Task after Mild Traumatic Brain Injury Is Associated with Impaired Early Object Exploration and Both Are Restored by Branched Chain Amino Acid Dietary Therapy

Journal of Neurotrauma
Rosalia PaternoAkiva S Cohen

Abstract

The relation between traumatic brain injury (TBI) and memory dysfunction is well established, yet imprecise. Here, we investigate whether mild TBI causes a specific deficit in spatial episodic memory. Fifty-eight (29 TBI, 29 sham) mice were run in a spatial recognition task. To determine which phase of memory might be affected in our task, we assessed rodent performance at three different delay times (3 min, 1 h, and 24 h). We found that sham and TBI mice performed equally well at 3 min, but TBI mice had significantly impaired spatial recognition memory after a delay time of 1 h. Neither sham nor injured mice remembered the test object locations after a 24-h delay. In addition, the TBI-specific impairment was accompanied by a decrease in exploratory behavior during the first 3 mins of the initial exposure to the test objects. These memory and exploratory behavioral deficits were linked as branched-chain amino acid (BCAA) dietary therapy restored both memory performance and normal exploratory behavior. Our findings 1) support the use of BCAA therapy as a potential treatment for mild TBI and 2) suggest that poor memory performance post-TBI is associated with a deficit in exploratory behavior that is likely to underlie the encodin...Continue Reading

References

Jan 31, 1992·Science·A Baddeley
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Jan 1, 1993·Annual Review of Neuroscience·S Zola-Morgan, L R Squire
Mar 7, 1998·Journal of Neurochemistry·K KanamoriR W Kondrat
Jul 14, 1998·Hippocampus·E Tulving, H J Markowitsch
Mar 22, 2001·Journal of Neurochemistry·E LiethS M Hutson
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Apr 16, 2004·Journal of Rehabilitation Medicine·Linda J CarrollUNKNOWN WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura L EldridgeBarbara J Knowlton
Sep 28, 2005·Brain Research. Brain Research Protocols·Ekrem DereMaria A De Souza Silva
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Oct 6, 2006·Journal of Neurotrauma·Mark D Whiting, Robert J Hamm
Mar 24, 2007·Current Opinion in Neurobiology·Marvin M Chun, Nicholas B Turk-Browne
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sean M Montgomery, György Buzsáki
May 14, 2008·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·Morris Moscovitch
Oct 2, 2009·Learning & Memory·Joseph R Manns, Howard Eichenbaum
Dec 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey T ColeAkiva S Cohen
Jan 12, 2010·Neuroscience and Biobehavioral Reviews·Erika Nyhus, Tim Curran
Dec 25, 2012·Neuron·David R EustonBruce L McNaughton
Jan 11, 2013·Journal of Neurotrauma·Michael J HylinPramod K Dash
Jan 29, 2013·Nature Neuroscience·György Buzsáki, Edvard I Moser
Dec 18, 2013·Science Translational Medicine·Miranda M LimAkiva S Cohen
May 14, 2017·Current Neurology and Neuroscience Reports·Rosalia PaternoAkiva S Cohen

❮ Previous
Next ❯

Software Mentioned

Matlab

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Journal of Clinical and Experimental Neuropsychology
M J RomanM Kracun
Archives of Physical Medicine and Rehabilitation
R Gomez-HernandezR G Robinson
Behavioural Neurology
Bonnie van GeldorpMarc P H Hendriks
Archives of Physical Medicine and Rehabilitation
Tessa HartThomas A Novack
© 2022 Meta ULC. All rights reserved