PMID: 8584214Oct 13, 1995Paper

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

Neuroscience Letters
I GordonD M Michaelson

Abstract

Apolipoprotein E-deficient mice provide a useful system for studying the role of apolipoprotein E (apoE) in the function of distinct neuronal systems. In the present study we focused on the cholinergic system of these mice. This was pursued by measurements of specific biochemical, physiological and cognitive parameters. Morris Water Maze tasks revealed impairments in working memory but not in reference memory of the apoE-deficient mice. Measurements of brain choline acetyltransferase activities revealed them to be markedly lower in the hippocampus and frontal cortex of the apoE-deficient mice than in the corresponding brain areas of the controls, but unaltered in other brain areas. In addition, hypothermia induced by the centrally acting muscarinic agonist, oxotremorine, was reduced in the apoE-deficient mice as compared to controls. These results show that apoE-deficient mice have cholinergic deficits and highlight the importance of this mouse model for studying the interactions between apoE and the cholinergic nervous system.

References

Jul 1, 1987·Biological Psychiatry·S C Dilsaver, N E Alessi
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 30, 1982·Science·R T BartusA S Lippa
Oct 13, 1995·Neuroscience Letters·I GenisD M Michaelson
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·E Grauer, J Kapon

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Citations

May 8, 2000·Journal of Neuroscience Research·L GenisD M Michaelson
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Feb 19, 2000·Biochemical and Biophysical Research Communications·V N Trieu, F M Uckun
Jun 18, 2009·Journal of Neural Transmission·Debra ToiberHermona Soreq
Jul 10, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ruby SultanaYu Nakamura
Jun 1, 1996·Trends in Neurosciences·H S Soininen, P J Riekkinen
Oct 13, 1995·Neuroscience Letters·I GenisD M Michaelson
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·L LomnitskiD M Michaelson
Apr 1, 1997·Pharmacology, Biochemistry, and Behavior·G A HigginsJ C Barnes
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·E MasliahW Samuel
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Jun 12, 1998·Brain Research. Brain Research Reviews·U BeffertJ Poirier
Mar 23, 2004·Behavioural Brain Research·Britto P NathanPaul V Switzer
Feb 13, 2001·Brain Research. Molecular Brain Research·C RamassamyJ Poirier
Jan 8, 1999·Neurobiology of Aging·J D SmithJ A Levin
Oct 28, 1999·Neurobiology of Aging·S Y Guénette, R E Tanzi
Jun 23, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·I VeinbergsE Masliah
Dec 1, 1996·Progress in Neurobiology·E MasliahW Samuel
Mar 15, 1996·Neuroscience Letters·I GordonD M Michaelson
Jul 31, 1998·Neuroscience Letters·I VeinbergsE Masliah
Mar 4, 1998·Neuroscience·T A RobertsonJ M Papadimitriou
May 21, 1999·Neuroscience·I Veinbergs, E Masliah
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O KleifeldD M Michaelson
Apr 2, 1999·Biochimica Et Biophysica Acta·L LomnitskiD M Michaelson
Jul 26, 2003·Brain Research. Cognitive Brain Research·So Ra KimYoung Choong Kim

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