Memory deficits following neonatal critical illness: a common neurodevelopmental pathway

The Lancet Child & Adolescent Health
Raisa SchillerDick Tibboel

Abstract

Over the past decade, evidence has emerged that children growing up after neonatal critical illness, irrespective of underlying diagnosis, are at risk of memory impairment and academic problems. These difficulties are manifest even when intelligence is within the normal range. In this Review, we propose a common neurodevelopmental pathway following neonatal critical illness by showing that survivors of preterm birth, congenital heart disease, and severe respiratory failure share an increased risk of long-term memory deficits and associated hippocampal alterations. Rather than a consequence of underlying diagnosis, we suggest that this shared vulnerability is probably related to common conditions associated with neonatal critical illness, including hypoxia, neuroinflammation, stress, exposure to anaesthetics, or a complex interplay of these factors at different postconceptional ages. Future work should be aimed at improvement of early identification of patients at risk and evaluation of intervention modalities, such as exercise or cognitive training.

Citations

May 16, 2020·European Journal of Anaesthesiology·Sophie A CosterusJurgen C de Graaff
Apr 7, 2018·Critical Care Medicine·Raisa M SchillerHanneke IJsselstijn
Jul 22, 2019·European Journal of Pediatrics·Annelieke HijkoopHanneke IJsselstijn
Aug 8, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ines VerlindenGreet Van den Berghe
Jul 8, 2021·Journal of Pediatric Surgery·Camille E van HoornJ Marco Schnater
Aug 12, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Camille E van HoornJurgen C de Graaff
Jul 30, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hanneke IjsselstijnAparna Hoskote
Dec 11, 2020·Journal of Pediatric Surgery·Unn Inger MoinichenRagnhild Emblem

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