Memory encoded throughout our bodies: molecular and cellular basis of tissue regeneration.

Pediatric Research
Marek DudasTai-Lan Tuan

Abstract

When a sheep loses its tail, it cannot regenerate it in the manner of lizards. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field. When a sheep loses it...Continue Reading

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Citations

Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Kirsten A BielefeldBenjamin A Alman
Mar 25, 2008·Pediatric Research·James C Y Dunn
Sep 23, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jennifer YehTai-Lan Tuan
Feb 27, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nicholas S GreavesArdeshir Bayat
Jul 19, 2020·Stem Cell Research & Therapy·Yongfa SunXiao Dong

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