Memory impairment in Parkinson's disease: The retrieval versus associative deficit hypothesis revisited and reconciled

Neuropsychology
Ondrej BezdicekRobert Jech

Abstract

Our study explored the retrieval deficit and the associative deficit hypotheses of memory impairments in Parkinson's disease (PD). The former supports a memory deficit mediated by attention/executive dysfunctions, whereas the latter hypothesizes a hippocampal memory impairment in PD. We studied 31 controls and 34 PD patients classified as PD with normal cognition (PD-NC; n = 18) and PD with mild cognitive impairment (PD-MCI; n= 16). To test the retrieval deficit hypothesis, we measured the performance in encoding, retention, and recognition in verbal and visual domains; to test the associative deficit hypothesis, we used a specific associative binding measure. Using resting-state functional-MRI, we compared the functional connectivity of different hippocampal subfields between PD patients and controls, and we related it to memory performance. Consistently with the retrieval deficit hypothesis, PD-MCI, and PD-NC, were impaired in free recall encoding and retention in comparison to controls, especially in the visual domain. However, as predicted by the associative deficit hypothesis, PD-MCI and, to a lesser extent, PD-NC, showed also significant associative and binding deficits in cued recall. Notably, PD patients compared to con...Continue Reading

Citations

Sep 25, 2020·Journal of the International Neuropsychological Society : JINS·Antònia Siquier, Pilar Andrés
Nov 18, 2020·Journal of Clinical and Experimental Neuropsychology·Filip HavlíkOndrej Bezdicek
Apr 17, 2021·Neuropsychology Review·Elizabeth R WallaceLisa M Koehl
Jul 3, 2021·Biomedicines·Mélina DecourtPierre-Olivier Fernagut

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