Memory impairment induced by different types of prolonged stress is dependent on the phase of the estrous cycle in female rats

Hormones and Behavior
Ezequiel Batista do NascimentoAlessandra M Ribeiro

Abstract

A growing body of evidence demonstrates that estrogen and corticosterone (CORT) impact on cognition and emotion. On the one hand, ovarian hormones may have beneficial effects on several neurophysiological processes, including memory. On the other hand, chronic exposure to stressful conditions has negative effects on brain structures related to learning and memory. In the present study, we used the plus-maze discriminative avoidance task (PMDAT) to evaluate the influence of endogenous variations of sex hormones and exposure to different types of prolonged stressors on learning, memory, anxiety-like behavior and locomotion. Female Wistar rats were submitted to seven consecutive days of restraint stress (4 h/day), overcrowding (18 h/day) or social isolation (18 h/day) and tested in different phases of the estrous cycle. The main results showed that: (1) neither stress conditions nor estrous cycle modified PMDAT acquisition; (2) restraint stress and social isolation induced memory impairments; (3) this impairment was observed particularly in females in metestrus/diestrus; (4) stressed females in estrus displayed less risk assessment behavior, suggesting reduced anxiety-like behavior; (5) restraint stress and social isolation, but n...Continue Reading

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Citations

Apr 3, 2020·Stress : the International Journal on the Biology of Stress·Qi SongBenno Roozendaal
Aug 24, 2021·Developmental Psychobiology·Natália C ZantaCarlos Eduardo Neves Girardi

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