Memory-induced nonlinear dynamics of excitation in cardiac diseases

Physical Review. E
Julian Landaw, Zhilin Qu

Abstract

Excitable cells, such as cardiac myocytes, exhibit short-term memory, i.e., the state of the cell depends on its history of excitation. Memory can originate from slow recovery of membrane ion channels or from accumulation of intracellular ion concentrations, such as calcium ion or sodium ion concentration accumulation. Here we examine the effects of memory on excitation dynamics in cardiac myocytes under two diseased conditions, early repolarization and reduced repolarization reserve, each with memory from two different sources: slow recovery of a potassium ion channel and slow accumulation of the intracellular calcium ion concentration. We first carry out computer simulations of action potential models described by differential equations to demonstrate complex excitation dynamics, such as chaos. We then develop iterated map models that incorporate memory, which accurately capture the complex excitation dynamics and bifurcations of the action potential models. Finally, we carry out theoretical analyses of the iterated map models to reveal the underlying mechanisms of memory-induced nonlinear dynamics. Our study demonstrates that the memory effect can be unmasked or greatly exacerbated under certain diseased conditions, which pr...Continue Reading

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Citations

Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Julian LandawZhilin Qu
Jul 18, 2021·Physical Review. E·Zhaoyang Zhang, Zhilin Qu
Dec 30, 2021·Circulation. Arrhythmia and Electrophysiology·Zhaoyang ZhangZhilin Qu

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