Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

Frontiers in Immunology
Kaitlyn M MorabitoBarney S Graham

Abstract

Tissue-resident memory T (TRM) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, TRM cells protect against respiratory infections, but wane more quickly than TRM cells in other tissues. This lack of a sustained TRM population in the lung parenchyma explains, at least in part, why infections with some pathogens, such as influenza virus and respiratory syncytial virus (RSV), recur throughout life. Intranasal (IN) vaccination with a murine cytomegalovirus (MCMV) vector expressing the M protein of RSV (MCMV-M) has been shown to elicit robust populations of CD8+ TRM cells that accumulate over time and mediate early viral clearance. To extend this finding, we compared the inflationary CD8+ T cell population elicited by MCMV-M vaccination with a conventional CD8+ T cell population elicited by an MCMV vector expressing the M2 protein of RSV (MCMV-M2). Vaccination with MCMV-M2 induced a population of M2-specific CD8+ TRM cells that waned rapidly, akin to the M2-specific CD8+ TRM cell population elicited by infection with RSV. In contrast to the natural immunodominance profile, however, coadministration of MCMV-M and MCMV-M2 did not suppress the M-specific CD8+ T cell response, sugges...Continue Reading

References

Oct 1, 1988·Journal of Medical Virology·B S GrahamD T Karzon
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urs KarrerPaul Klenerman
Feb 14, 2004·Journal of Virology·Urs KarrerPaul Klenerman
Mar 10, 2005·European Journal of Immunology·Sophie SierroPaul Klenerman
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lydie TrautmannMarc Bonneville
Nov 17, 2005·The Journal of Experimental Medicine·David A PriceDaniel C Douek
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael W MunksAnn B Hill
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian R HumphreysMichael Croft
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth K DayMark R Wills
Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher M SnyderAnn B Hill
Aug 20, 2010·European Journal of Immunology·Ian R HumphreysMichael Croft
Sep 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracy J RuckwardtBarney S Graham
May 19, 2011·European Journal of Immunology·Senta M WaltonAnnette Oxenius
Jan 10, 2012·Trends in Immunology·Geraldine A O'HaraRamon Arens
Sep 20, 2012·Medical Microbiology and Immunology·Christof K SeckertMatthias J Reddehase
Nov 13, 2012·The Journal of Clinical Investigation·Nicolas ÇuburuJohn T Schiller
Feb 14, 2013·European Journal of Immunology·Holly TurulaChristopher M Snyder
Feb 15, 2013·Science Translational Medicine·Federico SandovalEric Tartour
Mar 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lila A FarringtonChristopher M Snyder
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iryna DekhtiarenkoLuka Čičin-Šain
Mar 14, 2013·Oncoimmunology·Loane DecrausazDenise Nardelli-Haefliger
Feb 1, 2014·Journal of Leukocyte Biology·Kristin G Anderson, David Masopust
Jul 6, 2014·PLoS Pathogens·Corinne J SmithChristopher M Snyder
Jul 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter C L BeverleyElma Z Tchilian
Jul 30, 2014·Frontiers in Immunology·Hillary L Shane, Kimberly D Klonowski
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Mevyn NizardEric Tartour
Dec 20, 2014·Immunity·Jason M Schenkel, David Masopust
May 11, 2015·Cell·Elizabeth M SteinertDavid Masopust
Oct 1, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yun-Yan SunT-C Wu
Nov 4, 2015·Cell Reports·Corinne J SmithChristopher M Snyder

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Citations

Oct 20, 2019·Vaccines·Mario Alberto Ynga-DurandLuka Cicin-Sain
Jun 9, 2020·International Immunology·Shiki Takamura
Apr 21, 2019·Medical Microbiology and Immunology·Mladen JergovićJanko Nikolich-Žugich
Mar 11, 2019·Medical Microbiology and Immunology·Suzanne P M WeltenAnnette Oxenius
Jan 24, 2020·Cellular & Molecular Immunology·S C SassonL K Mackay
Jul 23, 2020·F1000Research·Gabrielle T BelzNicolas Jacquelot
Feb 16, 2020·Nature Reviews. Drug Discovery·Chih-Jen WeiGary J Nabel
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Demi BrownlieJakob Michaëlsson
May 18, 2021·Advanced Therapeutics·Frances C Knight, John T Wilson

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Methods Mentioned

BETA
PCR
Flow Cytometry
density gradient centrifugation
fluorescence-activated cell sorting

Software Mentioned

FlowJo
Pestle
GraphPad Prism

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