PMID: 9442586Jan 27, 1998Paper

Memory processes in depressed geriatric patients with and without subcortical hyperintensities on MRI

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
M JenkinsE Richardson

Abstract

In this study, 12 patients over age 60 with depression with moderate to severe subcortical hyperintensities (SH) localized to the periventricular white matter were identified by quantitative MRI. Using the California Verbal Learning Test, they were compared with 12 age-, education-, and severity-matched patients with depression with minimal white matter changes on specific aspects of memory performance. Patients with cortical lesions, neurologic or systemic illness affecting cognition, and history of substance abuse were excluded. Patients in the group with high SH showed reduced use of semantic encoding strategies (p < 0.05), reduced learning efficiency (p < 0.05), and a greater discrepancy between free recall and recognition discriminability (p < 0.05) than their low SH counterparts. This pattern of performance on memory tasks is similar to that found in previous studies to be associated with subcortical degenerative disorders such as Huntington's and Parkinson's diseases. Geriatric patients with depression with SH may represent a subgroup with greater subcortical involvement, with associated cognitive and functional decline.

References

Oct 1, 1990·Journal of Clinical and Experimental Neuropsychology·P J MassmanD P Salmon
Feb 1, 1990·Archives of Neurology·N WolfeM L Albert
Apr 1, 1990·Archives of Neurology·A KerteszT Carr
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation·H FukudaT Tsunematsu
Jan 1, 1989·Neuropsychologia·J S JanowskyL R Squire
Jan 1, 1989·Archives of Neurology·S M RaoG J Leo
Sep 1, 1987·Archives of Gerontology and Geriatrics·P S Goldman-Rakic
Jun 1, 1986·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·W JetterH J Markowitsch
Jun 30, 1967·Science·K H Pribram, W E Tubbs
Jan 1, 1994·The Journal of Neuropsychiatry and Clinical Neurosciences·M S Mega, J L Cummings
Oct 1, 1994·Archives of Neurology·A CorbettS Kos
Jun 1, 1993·Neuropsychologia·A Incisa della Rocchetta, B Milner
Oct 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·D A CahnR Westlake
Nov 1, 1995·Journal of the International Neuropsychological Society : JINS·M A WheelerE Tulving

❮ Previous
Next ❯

Citations

Dec 13, 2003·The Journal of Nervous and Mental Disease·Adam RosenblattConstantine Lyketsos
Oct 7, 2004·Aging Clinical and Experimental Research·Patrizia MecocciUmberto Senin
Jul 12, 2005·Cerebrovascular Diseases·Robert H PaulRonald A Cohen
May 3, 2011·European Journal of Applied Physiology·K J Hackney, L L Ploutz-Snyder
Aug 26, 2004·Journal of the International Neuropsychological Society : JINS·Virginia Elderkin-ThompsonAnand Kumar
Feb 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Sebastian KöhlerJohn T O'Brien
Dec 5, 2003·Journal of Geriatric Psychiatry and Neurology·Lawrence H SweetKelly D Garrett
Apr 5, 2001·International Journal of Geriatric Psychiatry·A J LloydI G McKeith
Feb 7, 2004·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Robert H PaulKelly Garrett
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·Sara L Wright, Carol Persad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.