Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation

Scientific Reports
Ana Paula CrestaniJorge Alberto Quillfeldt

Abstract

Memories can be destabilized by the reexposure to the training context, and may reconsolidate into a modified engram. Reconsolidation relies on some particular molecular mechanisms involving LVGCCs and GluN2B-containing NMDARs. In this study we investigate the interference caused by the presence of a distractor - a brief, unanticipated stimulus that impair a fear memory expression - during the reactivation session, and tested the hypothesis that this disruptive effect relies on a reconsolidation process. Rats previously trained in the contextual fear conditioning (CFC) were reactivated in the presence or absence of a distractor stimulus. In the test, groups reactivated in the original context with distractor displayed a reduction of the freezing response lasting up to 20 days. To check for the involvement of destabilization / reconsolidation mechanisms, we studied the effect of systemic nimodipine (a L-VGCC blocker) or intra-CA1 ifenprodil (a selective GluN2B/NMDAR antagonist) infused right before the reactivation session. Both treatments were able to prevent the disruptive effect of distraction. Ifenprodil results also bolstered the case for hippocampus as the putative brain structure hosting this phenomenon. Our results provi...Continue Reading

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Citations

Aug 25, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Thiago R da SilvaCristina A J Stern
Apr 29, 2018·Journal of Neurochemistry·Fabio Antonio Vigil, Karl Peter Giese
Nov 16, 2018·Psychological Reports·Yusuke NittaHiroaki Kumano
Jan 31, 2020·ELife·Bruno PopikLucas De Oliveira Alvares
Jan 10, 2017·Frontiers in Human Neuroscience·Rodrigo S FernándezMaría E Pedreira
Jun 14, 2019·Frontiers in Molecular Neuroscience·Natividade de Sá Couto-PereiraCarla Dalmaz
May 10, 2018·Scientific Reports·Lizeth K PedrazaLucas de Oliveira Alvares
Nov 4, 2020·Translational Psychiatry·Caroline F ZinkKristin L Bigos

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Methods Mentioned

BETA
Cognitive Behavioral Therapy

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