Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation

Neuroscience
M C KrawczykM Feld

Abstract

Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15 min after memory reactivation, and an inhibition at 45 min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40 min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation.

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Citations

Jun 21, 2016·Neurobiology of Learning and Memory·M C KrawczykM M Boccia
Feb 26, 2020·Annual Review of Neuroscience·Josué HaubrichKarim Nader
Oct 23, 2018·Frontiers in Molecular Neuroscience·Jorge H Medina, Haydee Viola
Jan 25, 2021·Behavioural Brain Research·Santiago Ojea RamosMariana Feld
Feb 13, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Burak TanCem Süer
Apr 13, 2021·IBRO Neuroscience Reports·Kurrey Khuleshwari, Paramanik Vijay

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