Memory-related changes of nitric oxide synthase activity and nitrite level in rat brain

Neuroreport
J ChenL Tang

Abstract

The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, NOS activity and nitrite level in hippocampus and cortex, and also the nitrite level in cerebellum, was elevated significantly one day after rats had learnt a water-rewarded spatial alteration task. These results suggest a spatial memory-related changes of endogenous NO in rat brain, and support the idea that NO participates in learning and memory processes.

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Citations

Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S M ChenB Rajanna
Apr 30, 2013·Archives of Biochemistry and Biophysics·Shuping WenNikolaj Klöcker
Jun 14, 2008·Biomedical and Environmental Sciences : BES·Jie YangJun-Wen Li
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Apr 11, 2007·Journal of Neurochemistry·María Laura PalumboAna María Genaro
Dec 21, 2007·The European Journal of Neuroscience·Blanca PiedrafitaVicente Felipo

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