Memory relationships between MRI volumes and resting PET metabolism of medial temporal lobe structures

Epilepsy & Behavior : E&B
H Randall GriffithBruce Hermann

Abstract

Prior studies of temporal lobe epilepsy (TLE) patients showed that MRI volumes and resting PET scan measures of temporal lobe structures were related to memory. Weintrob and colleagues [Ann. Neurol. 2002;51:442-7] reported that PET glucose uptake in the left perirhinal cortex predicted verbal paired associate (PA) learning, whereas MRI volume of the left hippocampus did not. We investigated whether MRI volumes could account for memory functioning if both PET and volumes were from the same region in 18 TLE patients. Volumes and glucose uptake of the hippocampus and parahippocampal gyrus (PHG) were compared with WMS-III performance. Significant correlations were observed between hippocampal volumes and PA and Logical Memory (LM) Percent Retention, but not between memory and PHG volumes or any PET measures. Multiple regression revealed that hippocampal volumes, but not PHG volumes or PET, significantly predicted PA and LM retention scores. These findings suggest that hippocampal volumes provide unique information regarding memory.

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Citations

Feb 17, 2007·Epilepsy Currents·Bruce Hermann, Michael Seidenberg
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Robert J ThomaJose M Cañive
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Michael SeidenbergLeslie Guidotti
Jun 7, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ralph L Cavalieri, Wayne R Cohen
Dec 12, 2007·Seminars in Pediatric Neurology·Bruce P HermannMichael Seidenberg
Dec 15, 2007·Epilepsy & Behavior : E&B·Carrie R McDonald
May 3, 2015·Neuroscience·N V Malykhin, N J Coupland
Jan 19, 2006·Epilepsia·Tayo O OyegbileBruce P Hermann
Nov 5, 2011·Epilepsia·William H TheodoreSusumu Sato
Jan 25, 2011·Epilepsy & Behavior : E&B·Thomas R Henry, Deborah D Roman
Jul 13, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Carrie R McDonaldVicente J Iragui
Sep 30, 2015·BioMed Research International·Jung Hwa LeeHyang Woon Lee
Oct 25, 2016·Epilepsy & Behavior : E&B·Sallie Baxendale, Pamela Thompson
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Sep 8, 2020·Neurocase·Andrea ZunigaArmin Nikpour
Feb 18, 2020·Epilepsy & Behavior : E&B·Agathe LaurentFrancine Chassoux

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