Memory retrieval and its lasting consequences

Neurotoxicity Research
Iván IzquierdoJorge H Medina

Abstract

Many, if not all psychiatric diseases are accompanied by memory disturbances, in particular, the dementias, schizophrenia, and, to an extent, mood disorders. Anxiety and stress, on the other hand, cause important alterations of memory, particularly its retrieval. Here we discuss several new findings on the basic mechanisms of consolidation, retrieval and extinction of a prototype form of episodic memory in the rat: conditioned fear. The findings point the way for investigations on the pathology of these aspects of memory in health and disease. Emphasis is placed on the parallel processing of retrieval in several cortical areas, on the links between retrieval and the onset of extinction, on the fact that extinction involves new learning requiring gene expression, and on the differences between the retrieval of recent or remote long-term memories.

References

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Citations

Aug 25, 2004·Neurotoxicity Research·Iván IzquierdoLía R M Bevilaqua
Aug 25, 2004·Neurotoxicity Research·Lionel Muller IgazJorge H Medina
Jun 25, 2013·Behavioural Brain Research·Marina A GrudenVladimir V Sherstnev
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jociane de Carvalho MyskiwIván Izquierdo
May 20, 2003·Neurotoxicity Research·Tomás PalomoRichard J. Beninger
Mar 17, 2010·Behavioural Brain Research·Ekrem DereReinhard Pietrowsky
Mar 27, 2007·Biochemical and Biophysical Research Communications·Lihui QuLei Yang
Nov 19, 2004·Brain Research. Molecular Brain Research·Lionel Müller IgazJorge H Medina
Feb 3, 2015·Behavioural Brain Research·Saraswathi SubramaniyanGert Lubec
Mar 3, 2015·Scientific Reports·Madelene Åberg AnderssonRoger Olsson
Nov 30, 2018·Neuropharmacology·Daniel Osorio-GómezFederico Bermúdez-Rattoni
Feb 27, 2020·Cell Reports·Maria Eugenia VillarMartin Giurfa
Oct 6, 2005·Learning & Memory·Mariana AlonsoJorge H Medina

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