MEMS-based adaptive optics scanning laser ophthalmoscopy

Optics Letters
Yuhua ZhangAustin Roorda

Abstract

We have developed a compact, robust adaptive optics (AO) scanning laser ophthalmoscope using a microelectromechanical (MEMS) deformable mirror (DM). Facilitated with a Shack-Hartmann wavefront sensor, the MEMS-DM-based AO operates a closed-loop modal wave aberration correction for the human eye and reduces wave aberrations in most eyes to below 0.1 microm rms. Lateral resolution is enhanced, and images reveal a clear cone mosaic near the foveal center. The significant increase in throughput allows for a confocal pinhole whose diameter is less than the Airy disc of the collection lens, thereby fully exploiting the axial resolution capabilities of the system.

References

Jul 1, 1981·IEEE Transactions on Bio-medical Engineering·R H Webb, G W Hughes
Nov 14, 1997·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·J LiangD T Miller
Sep 26, 2003·Investigative Ophthalmology & Visual Science·Aristofanis PallikarisHeidi Hofer
Oct 6, 2004·Optics Letters·B HermannP Artal
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Catherine BodenPamela A Sample
Nov 21, 2007·Optics Letters·Nathan DobleDavid R Williams
Nov 28, 2007·Optics Letters·E J FernándezP Artal
May 6, 2002·Optics Express·Austin RoordaMelanie Campbell
Jan 23, 2006·Optics Express·Curtis R VogelAlbert Parker
Apr 15, 1987·Applied Optics·R H WebbF C Delori
Feb 15, 1989·Applied Optics·A W DreherR N Weinreb

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Citations

Sep 4, 2009·Journal of Biomedical Optics·Seow-Hwang EngDouglas Chai
Oct 19, 2010·Journal of Neurology·Jeffrey M GelfandAri J Green
Nov 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Pooja GodaraJoseph Carroll
Feb 28, 2013·European Journal of Human Genetics : EJHG·Sung Pyo ParkStanley Chang
Sep 13, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Sung Pyo ParkStephen H Tsang
Apr 5, 2011·Journal of Biomedical Optics·Johnny Tam, Austin Roorda
Aug 30, 2012·Lasers in Surgery and Medicine·Adam BoretskyMassoud Motamedi
Mar 15, 2016·Annual Review of Vision Science·Austin Roorda, Jacque L Duncan
Apr 3, 2012·Journal of Biomedical Optics·Ningning KongLi Xuan
May 4, 2015·American Journal of Ophthalmology·Tianjiao ZhangYuhua Zhang
Oct 23, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Apr 23, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sung Pyo ParkStanley Chang
Oct 14, 2010·Optics Express·Minshan JiangShuliang Jiao
Jun 13, 2019·Seminars in Ophthalmology·Omar AbdelAlJennifer K Sun
Apr 25, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Johnny TamAustin Roorda
Dec 11, 2006·Optics Express·Kate GrieveAustin Roorda
Nov 26, 2010·Seminars in Ophthalmology·Babak Jian Seyedahmadi, Demetrios Vavvas
Apr 25, 2015·Biomedical Optics Express·Franz FelbererMichael Pircher
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Yuhua Zhang, Austin Roorda
Nov 29, 2012·Optics Express·Alfredo Dubra, Yusufu N Sulai
Jan 11, 2014·Biomedical Optics Express·Zhuolin LiuDonald T Miller
Nov 29, 2012·Optics Express·Hongbin YuTack Boon Yee
Aug 16, 2016·Optics Letters·Jing LuYuhua Zhang
Jan 4, 2018·Biomedical Optics Express·Xiao FeiYudong Zhang
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Kaccie Y Li, Austin Roorda
Oct 2, 2007·Applied Optics·Enrique J Fernández, Pablo Artal
Aug 30, 2019·Optics Letters·Vyas Akondi, Alfredo Dubra
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Stephen A BurnsDaniel X Hammer
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Diana C ChenScot S Olivier

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