Abstract
Primary hyperparathyroidism (PHPT) is a challenging problem in type 1 multiple endocrine neoplasia (MEN1) due to the high postsurgery recurrence rate. The aim was to evaluate the efficacy of cinacalcet in MEN1 patients in comparison with patients with sporadic PHPT (sPHPT) and the effect of Arg990Gly calcium-sensing receptor (CASR) polymorphism on the response to treatment. This is a randomized, crossover, double-blind study carried out in the University Hospitals. Fifteen MEN1 patients with PHPT were randomized to two groups, one administered with 30 mg daily cinacalcet, titrated until calcium normalization, and one with placebo. After 3 months, patients were reassessed and after washout switched to the other treatment. For comparison, 20 sPHPT patients with similar calcium levels were administered with cinacalcet for 3 months. Ionized and total calcium, phosphate, and parathyroid hormone (PTH) were evaluated. CASR Arg990Gly was genotyped on blood DNA by direct sequencing. Cinacalcet normalized calcium, increased phosphate, and reduced PTH levels in all patients. Cinacalcet dosage required to normalize calcium in MEN1 and sPHPT was not significantly different (45±21 vs 54±25 mg/day). Few mild adverse events, not requiring drug...Continue Reading
Citations
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Edward F Nemeth, Dolores Shoback
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·R Tyler Miller
May 12, 2015·Endocrine Journal·Yusuke ShibataMitsuhisa Komatsu
Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey A NortonRobert T Jensen
Apr 16, 2013·Best Practice & Research. Clinical Gastroenterology·Tetsuhide ItoRobert T Jensen
Feb 1, 2015·European Journal of Endocrinology·Aliya KhanMiklós Tóth
Jan 27, 2015·Annales d'endocrinologie·G Crouzeix, V Kerlan
Aug 11, 2016·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Takeshi SatoMasanori Adachi
Sep 8, 2016·European Journal of Endocrinology·C Verdelli, S Corbetta
Mar 3, 2018·Endocrine·Francesca MariniMaria Luisa Brandi
Oct 16, 2016·Scientific Reports·Alicja E GrzegorzewskaPaweł P Jagodziński
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Zeina HabibPauline Camacho
Sep 11, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A KhanJ P Bilezikian
Feb 1, 2013·Expert Opinion on Pharmacotherapy·Tetsuhide ItoRobert T Jensen
Mar 5, 2013·Expert Opinion on Pharmacotherapy·Nicolas VerheyenAndreas Tomaschitz
May 6, 2017·Frontiers in Endocrinology·Julius Simoni LeerePeter Vestergaard
Aug 1, 2015·Endocrine·Francesca GiustiMaria Luisa Brandi
Oct 14, 2019·Annales d'endocrinologie·Magaly VialonPhilippe Caron
Feb 11, 2021·Nature Reviews. Endocrinology·Abdallah Al-SalamehPhilippe Chanson
Mar 24, 2021·Clinical Therapeutics·Eman M Alfadhli