PMID: 3761040Apr 1, 1986Paper

Menaquinone (vitamin K2)-6 production by mutants of Flavobacterium meningosepticum

Journal of Nutritional Science and Vitaminology
Y TaniH Yamada

Abstract

Flavobacterium meningosepticum IFO 12535, a menaquinone (MK) producer, was mutagenized to improve productivity. A mutant, which was resistant to 1-hydroxy-2-naphthoate (HNA), was found to produce MK more abundantly: 34 mg/liter of culture broth and 5.5 mg/g of dry cells. The mutant was less sensitive to inhibition by HNA on MK biosynthesis than the wild-type strain. MK was isolated from cells of the mutant and identified as MK-6 based on its physicochemical characteristics. Mutants, which were given each KCN resistance, aromatic amino acid auxotrophy and no carotenoid productivity, did not show further increase of productivity.

Citations

Mar 24, 2016·Journal of Industrial Microbiology & Biotechnology·Yan LiuZhi-Ming Zheng
Aug 25, 2019·Bioprocess and Biosystems Engineering·Hengfang TangZhiming Zheng
Mar 5, 2017·Journal of Industrial Microbiology & Biotechnology·Zhemin LiZhiming Zheng
Oct 21, 2019·Biotechnology Advances·Lujing RenHe Huang

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