Mendelian randomization: a premature burial?

BioRxiv : the Preprint Server for Biology
George Davey Smith

Abstract

Mendelian randomization is a promising approach to help improve causal inference in observational studies, with widespread potential applications, including to prioritization of pharmacotherapeutic targets for evaluation in RCTs. From its initial proposal the limitations of Mendelian randomization approaches have been widely recognised and discussed, and recently Pickrell has reiterated these1. However this critique did not acknowledge recent developments in both methodological and empirical research, nor did it recognise many future opportunities for application of the Mendelian randomization approach. These issues are briefly reviewed here.

Related Concepts

Pharmacotherapy
Controlled Clinical Trials, Randomized
Evaluation
Empirical Research
Observational Study
Mendelian Randomization Analysis

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.