Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren

The American Journal of Clinical Nutrition
Lotte LauritzenCamilla T Damsgaard

Abstract

Background: Dietary and endogenously formed long-chain polyunsaturated fatty acids (LCPUFAs) are hypothesized to improve cognitive development, but results are inconclusive, with suggestions of sex specificity. One study suggested that single-nucleotide polymorphisms (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on erythrocyte LCPUFAs at 9 mo.Objective: To explore whether SNPs in FADS and elongase (ELOVL) genes were associated with school performance in a sex-specific manner, we performed a Mendelian randomization study using data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study with 765 Danish schoolchildren 8-11 y old.Design: Associations between selected FADS1/2 SNPs (rs1535, rs174448, and rs174468) and ELOVL5 rs2397142, whole-blood fatty acid composition, and performance in the d2 Test of Attention and a reading test were analyzed in multiple regression models including all SNPs, SNP-sex interactions, and covariates related to testing conditions.Results:FADS, rs1535 minor allele carriage associated with lower whole-blood arachidonic acid (P ≤ 0.002), and minor alleles of rs174448 tended to as...Continue Reading

Associated Clinical Trials

Oct 24, 2011·Arne Astrup

Citations

Jul 10, 2019·The Journal of Nutrition·Alessandra Mazzocchi, Carlo Agostoni
Dec 24, 2018·Nutrients·Dolores CorellaJose M Ordovas
Sep 28, 2018·Translational Psychiatry·Petroula ProitsiMarcus Richards
Nov 2, 2021·Evolution; International Journal of Organic Evolution·Jon Alexander HarperEdward H Morrow

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