Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats

The American Journal of Physiology
D A PodolinM J Pagliassotti

Abstract

Although fish oil supplementation may prevent the onset of diet-induced insulin resistance in rats, it appears to worsen glycemic control in humans with existing insulin resistance. In the present study, the euglycemic, hyperinsulinemic (4x basal) clamp technique with [3-3H]glucose and 2-deoxy-[1-14C]glucose was used to directly compare the ability of fish oil to prevent and reverse sucrose-induced insulin resistance. In study 1 (prevention study), male Wistar rats were fed a purified high-starch diet (68% of total energy), high-sucrose diet (68% of total energy), or high-sucrose diet in which 6% of the fat content was replaced by menhaden oil for 5 wk. In study 2 (reversal study), animals were fed the high-starch or high-sucrose diets for 5 wk and then the sucrose animals were assigned to one of the following groups for an additional 5 wk: high starch, high sucrose, or high sucrose with 6% menhaden oil. Rats fed the high-starch diet for 10 wk served as controls. In study 3 (2nd reversal study), animals followed a similar diet protocol as in study 2; however, the reversal period was extended to 15 wk. In study 1, the presence of the fish oil in the high-sucrose diet prevented the development of insulin resistance. Glucose infus...Continue Reading

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Citations

Sep 16, 2006·American Journal of Physiology. Cell Physiology·Zainisha VasanjiThomas Netticadan
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J S ThresherM J Pagliassotti
Jul 9, 2009·Obesity·Suzanne E DorfmanS Renee Commerford
Dec 30, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Justine M TishinskyLindsay E Robinson
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kim-Anne Lê, Luc Tappy
Apr 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Amy J DavidoffJun Ren
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S R CommerfordM J Pagliassotti
Aug 30, 2005·Metabolism: Clinical and Experimental·Michael E Bizeau, Michael J Pagliassotti
Jan 26, 2007·Diabetes Care·Raffaele De CaterinaErik Berg Schmidt
Mar 27, 2012·The Journal of Nutritional Biochemistry·Yu-Jen ChenShih-Torng Ding

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