PMID: 7041752Jan 1, 1981

Ménière's disease: endolymphatic sac decompression compared with sham (placebo) decompression

Annals of the New York Academy of Sciences
J ThomsenN J Johnsen


The placebo effect in surgery for Ménière's disease was investigated in a double-blind, controlled surgery by comparing the effect of a regular endolymphatic shunt with the effect of a purely placebo operation (regular mastoidectomy). Thirty patients with typical Ménière's disease participated in the study. They were selected for surgery because of unsuccessful medical treatment and were chosen randomly for each treatment group. The patients filled in daily dizziness questionnaires for 3 months before and 12 months after surgery, registering nausea, vomiting, vertigo, tinnitus, hearing impairment, and pressure in the ears. The patients were operated on in two university ENT departments. Those operated on in one department were controlled each month at the other department, and vice versa. At the termination of the trial, the investigators as well as the patients gave their overall opinion of the efficacy of the operation. Minor differences could be demonstrated between the active and the placebo group, but the greatest difference in symptoms was found when comparing pre- and postoperative scores, in which both groups improved significantly.


Sep 1, 1979·Archives of Otolaryngology·K F Plantenga, G C Browning
Apr 1, 1979·Clinical Otolaryngology and Allied Sciences·Jens ThomsenK Zilstorff
Jan 1, 1979·Advances in Oto-rhino-laryngology·R A Schindler
Sep 1, 1976·Acta Oto-laryngologica·J ThomsenK Zilstorff
May 1, 1977·Archives of Otolaryngology·I K Arenberg, G J Spector
Nov 1, 1977·The Laryngoscope·N Torok
Sep 16, 1976·Archives of Oto-rhino-laryngology·R S Kimura
Jan 1, 1980·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·L B Jongkees
Jan 1, 1980·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·D E Brackmann, R G Anderson
Mar 1, 1981·The Journal of Laryngology and Otology·J Sadé
May 1, 1964·Archives of Otolaryngology·G E Shambaugh


Aug 1, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Myeong Sang YuJong Woo Chung
Jun 22, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Isha TyagiRajan Syal
Jul 21, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Shahin Nabi, Lorne S Parnes
Jan 20, 2012·International Journal of Clinical Practice·I Syed, C Aldren
Aug 5, 2006·Brain, Behavior, and Immunity·Gustavo Pacheco-LópezManfred Schedlowski
Dec 21, 2017·F1000Research·K A WartolowskaAndrew Carr
Aug 23, 2006·ANZ Journal of Surgery·Ned S Abraham
Aug 12, 2005·The Laryngoscope·William F DurlandNadine P Connor
Feb 1, 1996·Anesthesia and Analgesia·J P WemamaR Krivosic-Horber
Apr 23, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Amit Justin SoodTed A Meyer
Mar 19, 2020·The British Journal of Surgery·S CousinsJ M Blazeby
May 11, 2018·Journal of the Royal Society of Medicine·K A WartolowskaA J Carr

Related Concepts

Clinical Trials
Double-Blind Method
Structure of Endolymphatic Sac
Membranous Labyrinth Structure
Ménière's Vertigo
Temporal Bone Structure

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