Meningeal afferent signaling and the pathophysiology of migraine

Progress in Molecular Biology and Translational Science
Carolina Burgos-VegaGregory Dussor

Abstract

Migraine is the most common neurological disorder. Attacks are complex and consist of multiple phases but are most commonly characterized by intense, unilateral, throbbing headache. The pathophysiology contributing to migraine is poorly understood and the disorder is not well managed with currently available therapeutics, often rendering patients disabled during attacks. The mechanisms most likely to contribute to the pain phase of migraine require activation of trigeminal afferent signaling from the cranial meninges and subsequent relay of nociceptive information into the central nervous system in a region of the dorsal brainstem known as the trigeminal nucleus caudalis. Events leading to activation of meningeal afferents are unclear, but nerve endings within this tissue are mechanosensitive and also express a variety of ion channels including acid-sensing ion channels and transient receptor-potential channels. These properties may provide clues into the pathophysiology of migraine by suggesting that decreased extracellular pH and environmental irritant exposure in the meninges contributes to headache. Neuroplasticity is also likely to play a role in migraine given that attacks are triggered by routine events that are typicall...Continue Reading

Citations

May 18, 2016·The Journal of Headache and Pain·Mária DuxGábor Jancsó
Nov 23, 2015·Cephalalgia : an International Journal of Headache·Alexander TzabazisDavid C Yeomans
Jan 27, 2018·Oncotarget·Alexander J SandweissTally M Largent-Milnes
Jun 11, 2019·Pharmacological Reports : PR·Agnieszka PiechalDagmara Mirowska-Guzel
Apr 27, 2019·Frontiers in Cellular Neuroscience·Duygu Koyuncu IrmakFatma Tore
Apr 27, 2018·Headache·David W Dodick
Nov 17, 2020·Frontiers in Neurology·Eun Hye OhJae-Hwan Choi
Sep 3, 2020·Journal of Ethnopharmacology·Ruifang YuanMing Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.