Meningeal carcinomatosis in patients with breast carcinoma. Clinical features, prognostic factors, and results of a high-dose intrathecal methotrexate regimen

Cancer
K FizaziP Pouillart

Abstract

This retrospective study evaluates the results of a regimen of high-dose intrathecal methotrexate and the prognostic factors for the response in patients with meningeal from breast carcinoma. From 1979 to 1994, 68 breast carcinoma patients were diagnosed with meningeal carcinomatosis at a mean age of 52 years. All but two had previous metastatic involvement. The proportion of lobular and ductal carcinomas was balanced. Malignant cells were present in cerebrospinal fluid (CSF) samples from 61 patients, whereas the 7 remaining patients had increased CSF protein associated with computerized tomographic scan evidence of meningeal metastases. From 1989, 41 of the patients received a regimen of high-dose intrathecal methotrexate with systemic folinic acid rescue (HD-MTX+FA): intrathecal MTX, 15 mg daily x 5 days, repeated every 2 weeks, and intrathecal hydrocortisone acetate, 125 mg on Day 1, and folinic acid, 10 mg intramuscularly 12 hours after each MTX injection. Systemic treatment and radiation therapy were usually associated. Patients treated before 1988 received intrathecal MTX in conventional doses (15 mg once a week). Clinical objective response, defined as a neurological improvement for at least one month, was achieved in 17...Continue Reading

References

Jul 1, 1978·Cancer·H Y YapG R Blumenschein
Jun 1, 1976·Cancer·J C Gonzalez-Vitale, R Garcia-Bunuel
May 1, 1992·Journal of Neuro-oncology·H NakagawaT Hayakawa
Jan 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L GiannoneJ D Hainsworth
Oct 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W BoogerdD Moffie
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R N HitchinsJ A Levi
Jan 1, 1987·Breast Cancer Research and Treatment·G Clamon, B Doebbeling
Jul 15, 1982·Cancer·H Y YapG R Blumenschein
Feb 1, 1984·Mayo Clinic Proceedings·S C SorensenM Scott
Sep 1, 1981·Journal of Neurosurgery·Y UshioH Mogami
May 15, 1982·Cancer·A S NarayanaD A Culp
May 1, 1994·Archives of Neurology·R GrantL Junck
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A GrossmanD S Ettinger

❮ Previous
Next ❯

Citations

Dec 11, 2002·The Lancet Oncology·John CrownMartine Piccart
Aug 19, 2008·Neuro-oncology·Laura HarstadMorris D Groves
Jul 5, 2007·Neurosurgical Focus·Robert Cavaliere, David Schiff
Jan 14, 2009·Journal of Neuro-oncology·F C BidardJ Y Pierga
Jul 22, 2010·Expert Review of Anticancer Therapy·Herwig Strik, Peter Prömmel
May 16, 2000·Cancer Investigation·S A Jeyapalan, T T Batchelor
Oct 1, 2014·Indian Journal of Cancer·A JoshiK Prabhash
Jun 27, 2013·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Millicent O ObajimiO O Akute
Apr 27, 2012·Clinical Neurology and Neurosurgery·Jose-Alberto PalmaEduardo Martinez-Vila
Nov 27, 2010·Neurosurgery Clinics of North America·Morris D Groves
Dec 26, 2008·Cancer·Jordi BrunaUNKNOWN Neuro-Oncology Unit of the Institute of Biomedical Investigation of Bellvitge
Dec 2, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W BoogerdCh J Vecht
Sep 1, 2004·Journal of the Neurological Sciences·Ulrich HerrlingerMichael Weller
Apr 25, 2006·Lancet Neurology·Beate Gleissner, Marc Charles Chamberlain
Apr 15, 2003·Neurologic Clinics·Santosh Kesari, Tracy T Batchelor
Aug 19, 2015·Journal of Korean Neurosurgical Society·Ho-Shin GwakSeung Hoon Lee
Feb 14, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Manisha KakRimas V Lukas
Jan 10, 2001·Current Opinion in Neurology·M C Chamberlain
Jul 12, 2016·International Journal of Molecular Sciences·Dae-Won LeeBhumsuk Keam
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Aug 2, 2003·Revista do Hospital das Clínicas·Tizuko MiyaguiKátia Martins Lopes de Azevedo
May 30, 2013·Surgical Neurology International·Emilie Le RhunMarc C Chamberlain
Jan 11, 2005·Surgical Neurology·Seiichi Yoshida, Ken Morii
Aug 25, 2007·Cancer Metastasis Reviews·Xiaoyun Cheng, Mien-Chie Hung
Feb 13, 2018·Journal of Neuro-oncology·Anna NiwińskaAgnieszka Jagiełło-Gruszfeld
Dec 21, 2002·Current Oncology Reports·Tali Siegal
Aug 30, 2000·Medical Oncology·S M Blaney, D G Poplack
Apr 9, 2008·Current Treatment Options in Oncology·M Brian Hemphill, Julia A Lawrence
Jun 21, 2007·Current Treatment Options in Neurology·Jan Drappatz, Tracy T Batchelor
Oct 11, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O MirF Goldwasser
Feb 17, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H YuN Kan
Oct 27, 2009·International Journal of Clinical Oncology·Hiromitsu YamakawaRyo Konno
Feb 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Petra FeyerRolf Sauer
May 1, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H GauthierV Diéras

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.