Meningioma: A Review of Clinicopathological and Molecular Aspects

Frontiers in Oncology
Kristin HuntoonSonika Dahiya

Abstract

Meningiomas are the most the common primary brain tumors in adults, representing approximately a third of all intracranial neoplasms. They classically are found to be more common in females, with the exception of higher grades that have a predilection for males, and patients of older age. Meningiomas can also be seen as a spectrum of inherited syndromes such as neurofibromatosis 2 as well as ionizing radiation. In general, the 5-year survival for a WHO grade I meningioma exceeds 80%; however, survival is greatly reduced in anaplastic meningiomas. The standard of care for meningiomas in a surgically-accessible location is gross total resection. Radiation therapy is generally saved for atypical, anaplastic, recurrent, and surgically inaccessible benign meningiomas with a total dose of ~60 Gy. However, the method of radiation, regimen and timing is still evolving and is an area of active research with ongoing clinical trials. While there are currently no good adjuvant chemotherapeutic agents available, recent advances in the genomic and epigenomic landscape of meningiomas are being explored for potential targeted therapy.

References

Nov 1, 1991·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M P BuetowJ G Smirniotopoulos
Apr 15, 1989·Cancer·D SofferM N Shalit
Nov 1, 1989·Journal of Neurosurgery·M RohringerA A Sima
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B R SeizingerR L Martuza
Oct 20, 1988·The New England Journal of Medicine·E RonL Katz
Mar 1, 1986·Clinical Genetics·T M StarinkA W Eriksson
Jan 1, 1985·Journal of Neurosurgery·R O MirimanoffR L Martuza
May 1, 1996·Nature Genetics·M R NelenC Eng
Sep 1, 1996·Journal of Neuro-oncology·M Bondy, B L Ligon
May 10, 1997·Lancet·T ShintaniN Kamada
Dec 31, 1997·The American Journal of Surgical Pathology·A PerryC M Lohse
May 7, 2002·Journal of Pediatric Hematology/oncology·Ted Zwerdling, Judith Dothage
Nov 27, 2002·Journal of Neurosurgery·Siegal SadetzkiDvora Nass
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Bruce E PollockShawn A Schreiner
May 24, 2003·Neurosurgery·Helle Collatz ChristensenChristoffer Johansen
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·D SIMPSON
Apr 1, 1961·Journal of Neuropathology and Experimental Neurology·J KEPES
Sep 26, 2003·Cancer·William M MendenhallWilliam A Friedman
Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Virginia E KimonisBehram Pastakia
Oct 11, 2005·Cancer Genetics and Cytogenetics·Fabio NunesMia MacCollin
Jul 11, 2006·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Martin HenzelRita Engenhart-Cabillic
Aug 30, 2008·Neurosurgery·Paul A GardnerDaniel M Prevedello
Sep 27, 2008·Annual Review of Pathology·Yong Sun Lee, Anindya Dutta
Nov 27, 2008·Orphanet Journal of Rare Diseases·Lorenzo Lo Muzio
Jul 17, 2010·Journal of the National Cancer Institute·Debra L FriedmanJoseph P Neglia
Aug 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stéphane GoutagnyMichel Kalamarides

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Citations

Jul 11, 2021·Neuro-oncology·Masaki Terabe, Jing Wu
Aug 10, 2021·JFMS Open Reports·Ivona OrgonikovaJosep Brocal
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Conor S GillespieMichael D Jenkinson

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Methods Mentioned

BETA
surgical resection
hormone replacement therapy
acetylation
dissection
biopsy
pharmacotherapy

Clinical Trials Mentioned

NCT01117844
NCT02693990
NCT00895622
NCT01125046
NCT03016091
NCT03279692
NCT02648997
NCT03604978
NCT03267836
NCT01880749

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