Meningiomas: An Overview of the Landscape of Copy Number Alterations in Samples from an Admixed Population

Journal of Oncology
Michele Amaral da SilveiraEdivaldo Herculano Corrêa de Oliveira

Abstract

Meningiomas are considered the most common intracranial tumors, affecting mainly women. Studies in mixed populations can be of great importance to clarify issues related to the genetic diversity of tumors and their development. Considering that data obtained from analyses of the profile of copy number alterations (CNA) have been a useful diagnostic indicator for many types of tumors and that meningiomas show a complex pattern of gains and losses in the number of copies, our objective was to analyze the CNA profile in 33 samples of meningiomas of different histological grades (WHO Grade I-III) from patients in a city located in the Amazon region of Brazil, using aCGH. We found that the female to male ratio was 3 : 1. The aCGH analysis revealed a total of 2304 CNA, with an average of 69.8 ± 57.4 per case, of which 1197 were gains (52%), 926 were losses (40.2%), 105 were amplifications (4. 5%), and 76 were deletions (3.3%). A significant relationship was observed between the type of CNA and the degree of the tumor (chi-square test: χ2 = 65,844; p < 0.0001; contingency coefficient: C = 0.1772; p < 0.0001). Evaluating the recurrent changes in at least 50% of the samples, we observe as the most frequent losses of the segments 22q13.1...Continue Reading

References

Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·R G WeberP Lichter
Dec 26, 2001·Cancer Genetics and Cytogenetics·S RiensteinE Friedman
Mar 14, 2007·Cancer Genetics and Cytogenetics·Antje-Friederike PelzChristian Mawrin
Jun 9, 2007·International Journal of Cancer. Journal International Du Cancer·Ralf KetterJörg Rahnenführer
Oct 17, 2007·Molecular Cancer·Lucia Helena CarvalhoAnita Lal
Jul 11, 2009·BMC Medical Genomics·Yiping ShenJames F Gusella
Nov 18, 2009·Journal of Neuropathology and Experimental Neurology·Darlene Gabeau-LacetGayatry Mohapatra
Sep 3, 2010·Journal of Neuro-oncology·Christian Mawrin, Arie Perry
Aug 3, 2012·Nature Reviews. Cancer·Brian E HendersonHongbing Shen
Feb 14, 2013·Acta Neuropathologica·David E ReussAndreas von Deimling
Feb 16, 2013·Methods in Molecular Biology·Gayatry MohapatraStephen Yip
Apr 26, 2014·Genetics and Molecular Biology·Francisco Mauro Salzano, Mónica Sans
Mar 26, 2016·Neurosurgery Clinics of North America·Wenya Linda BiIan F Dunn
Sep 12, 2016·Journal of Neuro-oncology·M BujkoJ A Siedlecki
Sep 15, 2016·Brain Tumor Pathology·Sayaka YuzawaShinya Tanaka
Apr 4, 2017·PloS One·Luis Eduardo Werneck de CarvalhoFernando Adami
Jan 6, 2018·Nature Reviews. Neurology·Matthias PreusserChristian Mawrin
Apr 18, 2019·Cancers·Gerhard JungwirthChristel Herold-Mende
May 10, 2019·Acta Neuropathologica·Nagarajan ParamasivamFelix Sahm
Jul 22, 2019·Cancer Epidemiology·Bernd HolleczekRalf Ketter
Sep 25, 2019·Cancers·Miguel Sánchez-ÁlvarezMarco Cordani
Oct 28, 2019·Cancers·Sungho LeeAkash J Patel
Nov 13, 2019·Journal of the Neurological Sciences·Natalie WaldtChristian Mawrin

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
Feature Extraction

Software Mentioned

Excel
GraphPad
Agilent Cytogenomics
GraphPad Prism
Feature Extraction

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives d'anatomie pathologique
A Pagès
Anales
R Landa Cannon
Neurology India
V Balasubramaniam, B Ramamurthi
Neurosurgical Focus
Steven L GiannottaWarren R Selman
© 2021 Meta ULC. All rights reserved