Meningiomas: Preoperative predictive histopathological grading based on radiomics of MRI.

Magnetic Resonance Imaging
Yuxuan HanChao Yang

Abstract

We aimed to develop a radiomics model to predict the histopathological grading of meningiomas by magnetic resonance imaging (MRI) before surgery. We recruited 131 patients with pathological diagnosis of meningiomas. All the patients had undergone MRI before surgery on a 3.0 T MRI scanner to obtain T1 fluid- attenuated inversion recovery (T1 FLAIR) images, T2-weighted images (T2WI) and T1 FLAIR with contrast enhancement (CE-T1 FLAIR) images covering the whole brain. The removing features with low variance, univariate feature selection, and least absolute shrinkage and selection operator (LASSO) were used to select radiomics features. Six classifiers were used to train the models (logistic regression (LR), k-nearest neighbor (KNN), decision tree (DT), support vector machine (SVM), random forests (RF), and XGBoost), and then 24 models were established using a random verification method to differentiate low-grade from high-grade meningiomas. The performance was assessed by receiver-operating characteristic (ROC) analysis, the f1-score, sensitivity, and specificity. The radiomics features were significantly associated with the histopathological grading. Quantitative imaging features (n = 1409) were extracted, and nine features were ...Continue Reading

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