Meningococcal B Vaccination (4CMenB) in Infants and Toddlers

Journal of Immunology Research
Susanna EspositoSamantha Bosis

Abstract

Neisseria meningitidis is a Gram-negative pathogen that actively invades its human host and leads to the development of life-threatening pathologies. One of the leading causes of death in the world, N. meningitidis can be responsible for nearly 1,000 new infections per 100,000 subjects during an epidemic period. The bacterial species are classified into 12 serogroups, five of which (A, B, C, W, and Y) cause the majority of meningitides. The three purified protein conjugate vaccines currently available target serogroups A, C, W, and Y. Serogroup B has long been a challenge but the discovery of the complete genome sequence of an MenB strain has allowed the development of a specific four-component vaccine (4CMenB). This review describes the pathogenetic role of N. meningitidis and the recent literature concerning the new meningococcal vaccine.

References

Sep 8, 2001·BMJ : British Medical Journal·H BedfordD Harvey
Jun 5, 2002·The Journal of Experimental Medicine·Maurizio ComanducciMarirosa Mora
Nov 16, 2002·American Journal of Respiratory and Critical Care Medicine·R Scott WatsonDerek C Angus
Apr 30, 2003·Archives of Disease in Childhood·S HalketD Harvey
Mar 24, 2007·Archives of Disease in Childhood·John de LouvoisDavid Harvey
Oct 9, 2007·Vaccine·Helen Bedford, Marilyn Lansley
May 30, 2009·Vaccine·Lee H HarrisonMary E Ramsay
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Davide SerrutoBeatrice Aricò
Oct 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·John DonnellyMarzia Monica Giuliani
Feb 15, 2013·Human Vaccines & Immunotherapeutics·Koen B PouwelsMaarten J Postma
May 11, 2013·Expert Review of Vaccines·Julie A BettingerDavid W Scheifele
Sep 26, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Matthew D SnapeAndrew J Pollard
Oct 15, 2013·Vaccine·Chiara AzzariUNKNOWN Italian Group for the Study of Invasive Bacterial Disease
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Roman PrymulaPeter M Dull
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Susanna EspositoDaniela Toneatto
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Gary W ZlotnickAnnaliesa S Anderson

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Citations

Sep 23, 2016·Expert Review of Vaccines·Susanna Esposito, Nicola Principi
May 10, 2016·Expert Review of Vaccines·Giulia PicciniEmanuele Montomoli

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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