PMID: 2506286Jul 1, 1989Paper

Meningococcal disease in Italy

The Journal of Infection
T StroffoliniP Mastrantonio

Abstract

In 1985, nationwide surveillance of meningococcal disease aimed at establishing appropriate guidelines for prophylaxis started in Italy. The incidence of disease was 1.1/100,000 in 1985 and 0.6/100,000 in 1987. This decreasing trend was particularly evident among military recruits (from 17.3/100,000 in 1985 to 5/100,000 in 1987), reflecting the use of bivalent serogroup (A + C) meningococcal polysaccharide vaccine in all new recruits since January 1987. The age distribution of cases was statistically different from that observed during the 1970s (P less than 0.001), with a shift towards older age groups. Men have been in the majority (516 vs. 358, P less than 0.0000001). Group C has been the most common serogroup encountered (72.2%), while only 18% of the isolates belonged to serogroup B. Among military recruits, serogroup C accounted for 92% (81/88) of the cases. The proportion of strains resistant to sulphonamides was 67%, while only 3% strains were resistant to rifampicin and to minocycline. Reduced susceptibility to ampicillin and to penicillin was observed in 3 and 4% strains respectively. Nine secondary cases were all due to failure in the administration of chemoprophylaxis (sulphonamide given in seven cases, prophylaxis ...Continue Reading

References

Mar 1, 1987·International Journal of Epidemiology·S L CochiV L Gurubacharya
Jan 1, 1983·Reviews of Infectious Diseases·H Peltola

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Citations

May 1, 1991·Irish Journal of Medical Science·G Corbett-Feeney
Feb 1, 1991·Epidemiology and Infection·P MastrantonioD A Caugant
Dec 22, 1999·Antimicrobial Agents and Chemotherapy·A BäckmanP Olcén

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