Meningococcal Vaccines: Current Status and Emerging Strategies

Vaccines
Pumtiwitt C McCarthyLaleh Sheikhi Moghaddam

Abstract

Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis is a public health burden to both developed and developing countries throughout the world. There are a number of vaccines (polysaccharide-based, glycoconjugate, protein-based and combined conjugate vaccines) that are approved to target five of the six disease-causing serogroups of the pathogen. Immunization strategies have been effective at helping to decrease the global incidence of meningococcal meningitis. Researchers continue to enhance these efforts through discovery of new antigen targets that may lead to a broadly protective vaccine and development of new methods of homogenous vaccine production. This review describes current meningococcal vaccines and discusses some recent research discoveries that may transform vaccine development againstN. meningitidisin the future.

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Citations

Jan 10, 2020·Journal of Clinical Microbiology·Cyrille H HaddarMuhamed-Kheir Taha
Apr 24, 2020·Expert Review of Vaccines·Amy C Sherman, David S Stephens
May 10, 2019·NPJ Vaccines·Emily KayBrendan W Wren
Sep 20, 2019·Journal of Aging Research·Gabriela Trzewikoswki de Lima, Elizabeth De Gaspari
Jan 25, 2020·Scientific Reports·Shikha TarangMichael D Weston
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Carmela IreneGuido Grandi
Jan 5, 2020·Journal of Biomedical Science·Ravinder MettuChung-Yi Wu
Dec 10, 2020·Vaccines·Priyal BagweMartin J D'Souza
Mar 23, 2021·World Journal of Microbiology & Biotechnology·Abhinay SharmaAtul Kumar Johri
May 28, 2019·Biomacromolecules·Majela Gonzalez-MiroBernd H A Rehm
Sep 9, 2021·Biochemical Society Transactions·Magdalena E ZasłonaOren Moscovitz
Dec 8, 2021·BMC Infectious Diseases·Stefan WalterAngel Gil de Miguel

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