Meningococcal vaccines. Global epidemiological situation and strategies for prevention by vaccination

Enfermedades infecciosas y microbiología clínica
Irene Rivero CalleFederico Martinón-Torres

Abstract

N. meningitidis is a major cause of meningitis and septicemia and a major public health problem in many countries. The disease, that can be fulminant, has a high mortality and may cause serious sequelae, even in cases of apparently optimal medical treatment. Chemoprophylaxis may prevent secondary cases among those in close contact with the ill, but, since secondary cases represent only 1%-2% of all meningococcal disease, chemoprophylaxis has a small impact when fighting most of endemic and epidemic forms. Given that al least 5% -15% of children and young adults are carriers, the fight against meningococcal disease based on chemotherapeutic elimination of nasopharyngeal colonization is virtually impossible. Therefore, immunization is the only rational way to combat this disease.

References

Jan 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·J D FarquharD P Metzgar
Dec 1, 1975·The Journal of Clinical Investigation·R GoldE C Gotschlich
Oct 23, 2001·Archives of Disease in Childhood·K ThorburnC A Hart
Mar 24, 2005·Infection and Immunity·Julia S BennettMartin C J Maiden
Jan 20, 2007·FEMS Microbiology Reviews·Dominique A CaugantPaula Kriz
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christoph SchoenMatthias Frosch
May 28, 2011·Expert Opinion on Biological Therapy·Xilian BaiRay Borrow
Sep 17, 2011·Expert Review of Vaccines·Donatella PanattoRoberto Gasparini
May 25, 2012·Vaccine·Steven B Black, Stanley A Plotkin
Aug 14, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K L SeibR Rappuoli
Sep 6, 2012·Médecine et maladies infectieuses·A BousquetA Mérens
Feb 19, 2013·The Lancet Infectious Diseases·Christopher J Gill
Oct 15, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·A GilJ A Vázquez
Nov 12, 2013·Lancet·Federico Martinón-Torres
Oct 11, 2014·Expert Review of Anti-infective Therapy·María Montero-MartínFederico Martinón-Torres
Feb 12, 2015·Archives of Disease in Childhood·Avishay SarfattiSimon Nadel
Dec 10, 2015·Revista española de salud pública·María Ángeles Onieva-GarcíaMaría Mar Mochón-Ochoa

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Citations

Nov 3, 2016·Scientific Reports·Federico Martinón-TorresUNKNOWN EUCLIDS consortium members - Imperial College London (www.euclids-project.eu)
Mar 15, 2016·The Pediatric Infectious Disease Journal·Irene Rivero-CalleUNKNOWN MENDICOS Research Network

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