Meniscal allograft transplantation in the sheep knee: evaluation of chondroprotective effects

The American Journal of Sports Medicine
Bryan T KellyScott A Rodeo

Abstract

Early protection of articular cartilage, before degenerative changes appear on radiographs, should result in better long-term results, but scientific evidence regarding the effectiveness of meniscal transplantation is lacking. To assess the chondroprotective effects of a new meniscal allograft transplantation animal model and evaluate a magnetic resonance imaging parameter, T2 mapping, in articular cartilage after meniscectomy and meniscal transplantation. Controlled laboratory study. Forty-five skeletally mature sheep were placed into 3 surgical groups: lateral meniscectomy (n = 24), meniscal allograft transplant (n = 17), and sham (n = 4). Animals were sacrificed at 2, 4, or 12 months. Cartilage was assessed by gross inspection, magnetic resonance imaging, T2 mapping, biomechanical testing, and semiquantitative histologic analysis. There were no differences between the sham operation and nonoperated control limbs. Compared with control limbs, meniscectomy resulted in significant increases in cartilage degeneration by all objective criteria (P < .01). Compared with meniscectomy, meniscal allograft transplantation resulted in significant decreases in cartilage degeneration (P < .02). There were significant correlations between ...Continue Reading

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Methods Mentioned

BETA
light microscopy
dissections

Software Mentioned

Functool
Metamorph

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