Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.

Arthritis Research & Therapy
Lorenzo Ramos-MucciBlandine Poulet

Abstract

Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. The aim of our study was to describe the pathological changes in menisci and ligament during disease development in murine spontaneous and post-traumatic surgically induced OA and to quantify tissue mineralisation in the joint space using micro-computed tomography (μCT) imaging during OA progression. Knees of Str/ort mice (spontaneous OA model; 26-40 weeks) and C57CBA F1 mice following destabilisation of medial meniscus (DMM) surgery (post-traumatic OA model; 8 weeks after DMM), were used to assess histological meniscal and ligament pathologies. Joint space mineralised tissue volume was quantified by μCT. Meniscal pathological changes in Str/ort mouse knees were associated with articular cartilage lesion severity. These meniscal changes included ossification, hyperplasia, cell hypertrophy, collagen type II deposition and Sox9 expression in the fibrous region near the attachment to the knee joint capsule. Anterior cruciate lig...Continue Reading

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Citations

Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Sahand Zanjani-PourEnrico Dall'Ara
Apr 4, 2021·International Journal of Molecular Sciences·Moon-Chang ChoiYoonkyung Park
Jun 23, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophia N ZiemianMarjolein C H van der Meulen
Sep 22, 2021·Science Signaling·Sarah E CathelineJennifer H Jonason

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