Meniscus formation during tracheal instillation of surfactant

Journal of Applied Physiology
F F Espinosa, R D Kamm

Abstract

The method of surfactant instillation into the lungs for treatment of neonatal respiratory distress syndrome is an important attribute of delivery, and it may determine the overall efficacy of treatment. Previous studies primarily focused on the rate at which the bolus is instilled. These findings show that rapid injections lead to a more homogenous distribution, whereas slow infusions drain into the dependent lung with respect to gravity, resulting in a heterogeneous deposition. These results suggest that it is beneficial to form a meniscus, from which a more homogenous dispersal can proceed. The objective of the present study was to develop a functional criterion for meniscus formation during bolus injection. An in vitro experiment was used to examine the clinical setting of surfactant instillation. The physical variables examined were the bolus viscosity (mu) and density (rho), gravity (g), injection rate (Q), orientation of the trachea with respect to gravity (theta), tracheal size (D), surface tension (gamma), and catheter size (d). All quantities were varied, except gravity and catheter size. Experimental results show that a meniscus will form when NSt > 0. 004Re2/3, where NSt is Stokes number and Re is Reynolds number, N...Continue Reading

Citations

Jul 22, 2018·Journal of Biomechanical Engineering·Antonio CopploeHossein Tavana
Jul 12, 2001·Annual Review of Biomedical Engineering·J B Grotberg
Jan 14, 1999·Journal of Applied Physiology·F F Espinosa, R D Kamm
Nov 17, 2004·Journal of Biomechanical Engineering·D HalpernJ B Grotberg
Dec 13, 2006·Journal of Biomechanical Engineering·Stefano TrediciJoseph L Bull
Sep 26, 2006·Journal of Biomechanical Engineering·Y ZhengJ B Grotberg
Oct 27, 2005·Journal of Biomechanical Engineering·Y ZhengJ B Grotberg
Mar 16, 2011·Physics of Fluids·James B Grotberg
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Marcel FilocheJames B Grotberg
Mar 3, 2004·Journal of Applied Physiology·Joseph C AndersonJames B Grotberg
Dec 23, 2003·Journal of Applied Physiology·J L BullR B Hirschl
Dec 19, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Hossein TavanaShuichi Takayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Colloid and Interface Science
A C Rust, Michael Manga
Journal of Colloid and Interface Science
Yu-Rong ChangPing-Yao Wu
Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
J R Johnston, R C Schroter
© 2022 Meta ULC. All rights reserved