Menopausal hormone therapy and mild cognitive impairment: a randomized, placebo-controlled trial

Menopause : the Journal of the North American Menopause Society
Byung-Koo YoonDuk L Na

Abstract

The aim of the study was to explore the therapeutic potential of menopausal hormone therapy (MHT) in women with mild cognitive impairment (MCI). Thirty-seven postmenopausal women (age range: 57-82 y) with multiple-domain, amnestic subtype MCI were randomly assigned to either placebo (n = 18) or MHT (n = 19) for 24 months (percutaneous estradiol [E2] gel [0.1%, 2 mg/d] and oral micronized progesterone [MP4] [100 mg/d]). All participants received donepezil, and apolipoprotein E genotype was determined. The primary endpoint was general cognitive function: Alzheimer's disease Assessment Scale, cognitive subscale, the Korean version of Mini-Mental State Examination (K-MMSE), and the Korean version of the Montreal Cognitive Assessment (MoCA_K) were performed in-person every 6 months. Twenty-one participants (placebo 13, MHT 8) completed the trial (56.8%). Progression rates to dementia were 52.9% (9/17) in the placebo group and 44.4% (8/18) in the MHT group. Within-group analysis showed that all three tests significantly worsened during the trial in the placebo, but not the MHT groups. Analysis adjusted for ε4 allele demonstrated that MHT significantly reduced deterioration of MoCA_K score, a sensitive tool for assessing global cognit...Continue Reading

References

Oct 1, 1992·Psychoneuroendocrinology·S M Phillips, B B Sherwin
Apr 1, 1997·Journal of Women's Health·R S BermanE Lydick
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Mar 23, 2001·JAMA : the Journal of the American Medical Association·E S LeBlancH D Nelson
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Susan M Resnick, Victor W Henderson
Jan 15, 2003·Neurology·A S RigaudUNKNOWN French Study Group
Aug 19, 2003·Human Psychopharmacology·Seong Hye ChoiHellmut Erzigkeit
Mar 17, 2004·Journal of Geriatric Psychiatry and Neurology·Sue J KangDuk L Na
Jun 24, 2004·JAMA : the Journal of the American Medical Association·Sally A ShumakerUNKNOWN Women's Health Initiative Memory Study
Apr 15, 2005·The New England Journal of Medicine·Ronald C PetersenUNKNOWN Alzheimer's Disease Cooperative Study Group
Jul 19, 2005·Annals of the New York Academy of Sciences·Margarita Alvarez-de-la-RosaFrederick Naftolin
Apr 16, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Lyzel S Elias-SonnenscheinPieter Jelle Visser
Jun 19, 2013·Molecular Neurobiology·Jung Hoon LeeMin Jae Lee
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Victor W HendersonWendy J Mack
Dec 2, 2014·Neuroscience and Biobehavioral Reviews·L A BarrosM L Andersen
Dec 17, 2014·JAMA : the Journal of the American Medical Association·Kenneth M Langa, Deborah A Levine
Apr 30, 2015·Hormones and Behavior·Maria-Angeles ArevaloLuis M Garcia-Segura
May 27, 2015·Psychoneuroendocrinology·Alison Berent-SpillsonYolanda R Smith
Jul 1, 2015·Hormones and Behavior·Paula Duarte-GutermanLiisa A M Galea
Jul 19, 2015·Hormones and Behavior·Paul Newhouse, Julie Dumas
May 11, 2016·Journal of Alzheimer's Disease : JAD·Kejal KantarciVirginia M Miller
Jan 25, 2017·Climacteric : the Journal of the International Menopause Society·H P G Schneider, M Birkhäuser

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Citations

Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yongming PanFuliang Hu
May 28, 2020·Frontiers in Aging Neuroscience·Monica A WagnerYvette P Conley
Nov 21, 2019·Journal of Alzheimer's Disease : JAD·Katrine Yare, Michael Woodward
Feb 11, 2021·Nutrients·Nicolas CollazoMiguel A Prieto
Mar 12, 2021·Climacteric : the Journal of the International Menopause Society·Y Li, J-C Dreher
Aug 28, 2021·International Journal of Molecular Sciences·Ya-Ting ChangHong-Yo Kang
Dec 2, 2021·Advances in Nutrition·Jonathan BortzTaylor C Wallace

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